National Research Nuclear University MEPhI

Cellular and Tissue Mechanisms of Laser-Assisted Regeneration of Tympanic Membrane Perforation

Chronic tympanic membrane (TM) perforations remain a significant clinical problem due to limited spontaneous healing and the drawbacks of surgical interventions. The present study aimed to evaluate the effects of low-intensity infrared laser irradiation on cellular mechanisms of...

Application of Machine Learning Methods for Processing and Analyzing Data from Probe and Optical Microscopy of Biological Objects

Abstract This review systematizes modern machine learning (ML) methods for solving key image processing tasks in optical microscopy (OM) and atomic force microscopy (AFM). Traditional microscopy data analysis methods face problems of subjectivity, low throughput, and difficulty i...

Study of the Characteristics of the BBC Detector Prototype

Abstract One of the subsystems of the SPD experiment (phase I) is the Beam Counter (BBC), designed as high-granularity scintillation detector with a segmented structure of ~800 channels. To ensure its reliability, a quick tool to check entire optoelectronic path is needed. We pre...

Sensitivity of Flow Harmonics to the Equation of State of Strongly Interacting Matter in Heavy-Ion Collisions at Nuclotron-NICA Energies

The main goal of beam energy scan programs in heavy-ion collisions is to investigate the equation of state (EoS) and explore possible phase transitions in strongly interacting matter. Anisotropic flow, quantified from the azimuthal distributions of produced particles, is a key ob...

Criterion-Based Method for Evaluating Material Strength Utilizing Reference Reflexes of Electrical Potentials

Utilizing continuum medium models and the electron work function, a linear correlation was established connecting mechanical stresses to the electric potential difference in the surface layers of a metal. It was demonstrated that, given a metallic surface in the major stress coor...

Quantum Dot Bioconjugates Enable Order(s)-of-Magnitude Enhancement of Immunoglobulin E Detection Sensitivity

Abstract Improving the sensitivity of immunoglobulin E (IgE) detection is crucial because the concentrations of allergen-specific IgE antibodies are often very low, particularly at early sensitization stages or in patients with weak immune responses. Bright, photostable detection...

Linking In Vivo Imaging to Therapeutic Outcome with 131I, 177Lu, 188Re Nanoparticles

Nanoparticles are increasingly explored as carriers for therapeutic radionuclides in oncology, offering prolonged circulation, high payload capacity, and active targeting. Radiolabeling enables non-invasive tracking of these constructs by SPECT or PET, providing biodistribution d...