National Research Institute of Chinese Medicine

Pseudobulb Yield and Chemical Quality of Field-Grown Bletilla formosana in Guangfu, Hualien, Across Cultivation Years and Harvest Seasons

Bletilla formosana is an important medicinal orchid in Taiwan, but information on how cultivation year, harvest season, and pseudobulb size are associated with yield and chemical quality under field conditions remains limited. This study evaluated field-grown B. formosana in Guan...

Soluble N-terminal EphA2 fragment as a diagnostic biomarker and functional mediator of tumor progression in triple-negative breast cancer

Triple-negative breast cancer (TNBC) lacks reliable biomarkers for early detection and remains a highly aggressive disease. Ephrin type-A receptor 2 (EphA2), a receptor tyrosine kinase frequently overexpressed in advanced cancers, undergoes MMP14-mediated cleavage that releases s...

Total Syntheses and Structural Reassignment of Ugonin T and Neougonin B: Anti-inflammatory Flavonoids Related to Helminthostachys zeylanica

Abstract This study reports the first total syntheses of the naturally occurring flavonoids ugonin C (1), ugonin F (2), and, based on the originally proposed structures, compounds 3 and 4 (corresponding to the structures first assigned to ugonin T and neougonin B, respectively),...