National Research Foundation

Targeted Strategies for Treatment of Colorectal Cancer: Exploring the Use of Aptamers and Gold Nanoparticles

Colorectal cancer (CRC) is the second leading cause of cancer-associated mortality and accounts for ~10% of all cancer cases. Global CRC cases were estimated at 1.9 million and 930,000 deaths in 2022. Despite improved access to CRC screening and treatment, death rates are expecte...

Reciprocal Genome Projection Reveals Reference-Conditioned Functional Variation in Clinical Aspergillus Section Nigri Isolates

Closely related Aspergillus section Nigri species are difficult to resolve taxonomically, while short-read comparisons may be influenced by reference-genome choice. We applied reciprocal genome projection to 31 whole-genome sequencing libraries representing South African clinical...

In vitro antioxidant activity and cytotoxic effects of sulfated galactan polysaccharides from Gracilaria spinulosa

This study investigated the extraction, chemical composition, structural characteristics, antioxidant activity, and in vitro cytotoxic potential of sulfated galactan polysaccharides (SGP) isolated from the red seaweed Gracilaria spinulosa collected from the Gulf of Mannar, Tamil...