National Research Center for Maternal and Child Health

Eleven-Year Trends in Stillbirth, Neonatal and Infant Mortality and Birthweight-Specific Risk: A BABIES Matrix Analysis from a Tertiary Maternity Center in Kazakhstan, 2015–2025

Background/Objectives: Long-run facility-level perinatal data from Central Asia are scarce. We described eleven years of stillbirth, neonatal, infant and perinatal mortality at one tertiary maternity center in Kazakhstan, and used the Birthweight and Age-at-death Boxes for Interv...

Gut microbiota functional remodeling and butyrate depletion amplify anti-Ro/La antibody-driven type I interferon activation in neonatal lupus

The early-life gut microbiome may influence susceptibility to antibody-mediated neonatal autoimmunity, but the underlying mechanisms remain poorly understood. We investigated whether gut microbial functional capacity and metabolites influence autoantibody-dependent immune activat...

Trends in cardiovascular disease mortality in Kazakhstan and the impact of the COVID-19 pandemic: a national health data analysis

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. While the impact of COVID-19 on trends is recognized, it is uncertain whether these patterns continued into the third pandemic year. This study sought to investigate the mortality patterns of CVDs during 201...

Pilot Evaluation of ddPCR-Based NIPT for Fetal Trisomy Screening in Advanced-Maternal-Age Pregnancies in Mongolia

Background/Objectives: Advanced maternal age (≥35 years) significantly increases the risk of fetal chromosomal abnormalities, particularly trisomies 21, 18, and 13. Non-invasive prenatal testing (NIPT) based on cell-free fetal DNA (cffDNA) in maternal plasma has substantially imp...