National Medical Products Administration

Comprehensive role of fluorine-18-labeled fluorodeoxyglucose PET/computed tomography across the disease course of primary malignant melanoma of the esophagus

This study aimed to evaluate the clinical value of fluorine-18-labeled fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT) in managing primary malignant melanoma of the esophagus (PMME). Seventy patients with pathologically confirmed PMME between September 2011 and June 202...

Pharmacokinetic and safety interactions between aildenafil and clarithromycin, cimetidine, or rifampin in healthy subjects

Aims Aildenafil citrate, an orally bioavailable phosphodiesterase type 5 (PDE5) inhibitor, is primarily metabolized by cytochrome P450 3A4 (CYP3A4). This study aimed to assess potential pharmacokinetic interactions between aildenafil citrate tablets and cytochrome P450 (CYP)3A mo...

Regional alterations in bone microstructure, muscle, and fat of the knee following anterior cruciate ligament rupture: a laboratory study in rabbit model

To investigate the temporal alterations in bone, muscle, and fat tissues in an anterior cruciate ligament transection (ACLT) rabbit model. A total of 24 male New Zealand White rabbits underwent ACLT in the right knee. The animals were euthanized at 3, 6, 9, and 12 weeks post-ACLT...

The illusion of clinical reasoning: a benchmark reveals the pervasive gap in vision-language models for clinical competency

The rapid integration of foundation models into clinical practice and their use for public health inquiries necessitates a rigorous evaluation of their true clinical reasoning capabilities, which extends beyond success on narrow examinations. Current benchmarks, often based on me...

CXCR4-targeted dual softener for inducing senescence therapy in hepatic fibrosis

Hepatic fibrosis is a central pathological driver of chronic liver diseases, including metabolic dysfunction-associated steatotic liver disease and alcohol-related liver disease, which collectively impose a growing global health burden. Fibrosis is primarily mediated by persisten...

Identification of Impurities in Norvancomycin Hydrochloride Drug Substance Using UHPLC‐QTOF‐MS

ABSTRACT Rationale Norvancomycin (NVCM) hydrochloride belongs to a group of glycopeptide antibiotics and exhibits strong effects against Gram‐positive cocci and bacilli. The safety of patients' lives is directly related to the quality of drugs. The impurities play often an import...

Checkpoint-insulated triple-signal artificial antigen-presenting cells drive antigen relay and systemic antitumor immunity

Dendritic cell (DC) vaccines offer professional antigen presentation but are often limited by suboptimal trafficking to lymphoid tissues, whereas whole tumor cell vaccines preserve antigenic diversity yet frequently lack coordinated activation cues for efficient T cell priming. H...

Identification of cognitive subtypes and risk networks in Chinese older adults: based on latent profile analysis and explainable machine learning

Traditional cognitive screening often relies on total scores, which can easily mask asynchronous impairment patterns across different cognitive domains. In particular, calculation ability, a sensitive indicator of executive function, is frequently misattributed to normal aging an...

Quality of postoperative recovery in patients undergoing laparoscopic colorectal cancer resection as affected by transversus abdominis plane block combined with moderate neuromuscular blockade: a randomized controlled trial

Postoperative recovery quality in laparoscopic surgery may benefit from deep neuromuscular blockade, whereas the effects of combining transversus abdominis plane block (TAPB) with moderate neuromuscular blockade in this regard remain unreported. This work investigated whether mod...

Prevalence of disease related malnutrition assessed by NRS2002, STAMP, MNA-SF, one-step and two-step GLIM at admission and discharge: A systematic review and meta-analysis.

BACKGROUND AND OBJECTIVES: Disease-related malnutrition (DRM) mandates routine screening in many nations to ensure quality care as nutritional status often deteriorates during hospitalization. This study aimed to establish tool-specific prevalence benchmarks at admission and disc...