National Marrow Donor Program

GRIMM-II: A two-stage real-time algorithm for nine-locus HLA imputation and matching with up to three mismatches

Background: The success of hematopoietic stem cell transplantation (HSCT) depends critically on human leukocyte antigen (HLA) matching between donor and recipient. While traditional matching focuses on five classical HLA loci (A, B, C, DRB1, DQB1), clinical practice increasingly...