National Marrow Donor Program

ATG exposure in T replete transplant for hematological malignancies: Real world analysis from BMT CTN 1202

Traditional weight-based dosing results in variable rabbit anti-thymocyte globulin (rATG) clearance, delaying CD4+Tcell-immune-reconstitution (CD4 + IR) and impacting outcomes. In a retrospective pharmacokinetic/pharmacodynamic analysis of patients undergoing first T-replete hema...

GRIMM-II: A two-stage real-time algorithm for nine-locus HLA imputation and matching with up to three mismatches

Background: The success of hematopoietic stem cell transplantation (HSCT) depends critically on human leukocyte antigen (HLA) matching between donor and recipient. While traditional matching focuses on five classical HLA loci (A, B, C, DRB1, DQB1), clinical practice increasingly...