National Institutes of Health Clinical Center

Aspiration and silent aspiration in Niemann-Pick disease type C1: longitudinal findings from the NIH natural history study

Abstract Background Niemann–Pick disease type C1 (NPC1) is a rare neurodegenerative disorder in which dysphagia is common and aspiration pneumonia is a leading cause of mortality. Aspiration may be clinically apparent or silent, reflecting impaired airway sensation and protective...

Improved allocation strategies for red cell units of blood group O and RhD-negative revealed by current suboptimal utilization

Abstract Background Demand for O RhD-negative red cells continues to rise, while overall red cell transfusions have decreased, compounding inventory management challenges. We analyzed O RhD-negative red cell utilization in a large publicly available database. Methods Data from 37...