National Institute on Deafness and Other Communication Disorders

Epithelial-mesenchymal Wnt crosstalk directs planar cell polarity in the developing cochlea

Cochlear hair cells are precisely oriented by planar cell polarity. Wnt proteins direct planar cell polarity in vertebrates, but their roles in regulating cochlear planar cell polarity remain unclear. Here, we inhibit Wnt secretion by ablating epithelial Wntless and find shortene...