National Institute of Science and Technology

Thermodynamic Decoupling at the Planck Boundary: The t=0 Non-Thermal Pure State Blueprint

This paper challenges the prevailing assumption of a "Hot Singularity" in standard cosmology by rigorously re-evaluating the physical properties of the universe at the exact coordinate of t=0. Relying on canonical quantum mechanics and statistical thermodynamics, we argue that th...

Beyond Tumor-Intrinsic STAT3: Integrating Metabolic and Immune Communication in the Tumor Microenvironment of Cervical, Ovarian, and Endometrial Cancers

Cervical, ovarian, and endometrial cancers comprise biologically distinct malignancies with substantial heterogeneity in their molecular alterations, metabolic dependencies, immune landscapes, and therapeutic responses. Despite advances in surgery, chemotherapy, radiotherapy, tar...

Multi-omics analysis reveals Protein Kinase A-associated regulatory remodeling during adaptation of Trichoderma reesei to lignocellulosic substrate

The filamentous fungus Trichoderma reesei is a major industrial source of holocellulolytic enzymes, and its response to complex carbon sources is regulated by nutrient-sensing mechanisms, including the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway...

Regulation in ecological systems: an organizational approach

The term “regulation” is often used in biology to refer to the means by which a system keeps or returns to a certain state after perturbation. Feedback mechanisms and the propagation of the perturbation through a network of constitutive components are commonly associated with thi...

Second-Order Chemometric Classification of Candida Species Using Excitation–Emission MatrixFluorescence Spectroscopy: A Proof-of-Concept Study

Abstract Microorganisms of the genus Candida are responsible for a wide range of fungal infections and are associated with increased morbidity and mortality rates. Although several clinical methods are available for the diagnosis of candidiasis, they have limitations related to r...

Rethinking Plasticity in Sponges

What lies behind the extraordinary phenotypic plasticity of sponges? We used this question to conduct a systematic review of how "phenotypic plasticity" is approached in the literature regarding the phylum Porifera. First, we gathered information on what the literature says about...