National Institute of Pharmaceutical Education and Research

A Modification-Free Microneedle-Integrated Printed Electrochemical Sensor for Uric Acid Detection in Artificial Skin

Abstract The integration of microneedles (MNs) with electrochemical biosensors is a promising strategy for minimally invasive detection of metabolites from interstitial fluid (ISF). Conventional MN-based sensing platforms typically rely on conductive coatings or surface functiona...

Safety and efficacy of indigenous ultrathin-strut versus international thin-strut drug-eluting coronary stents in percutaneous coronary intervention: a systematic review of randomized controlled trials

Introduction Ultrathin-strut drug-eluting stents (DES) have been developed to enhance vascular healing and reduce restenosis following percutaneous coronary intervention (PCI). Indigenous biodegradable-polymer ultrathin-strut DES are increasingly used in high-burden settings; how...

Two‐Step, Telescopic Synthesis of Unsymmetrical Urea via Integration of Denitrogenative Methyl N ‐Arylcarbamates Formation and Their Aminolysis

Unsymmetrical ureas are valuable structural motifs in pharmaceuticals, agrochemicals, and functional materials; however, their synthesis often relies on toxic reagents, transition metals, or isocyanate intermediates, resulting in poor sustainability and limited scalability. Herei...

Integrated In Silico and Experimental Insights into Immunomodulatory Toll-Like Receptor 7/8 Agonists with Anticancer Potential

Abstract Toll-like receptors (TLRs) are key pattern recognition receptors that play a central role in regulating and bridging both innate and adaptive immune responses. Notably, TLR7 and TLR8 agonists have gained significant attention as promising therapeutic candidates because o...

Rational Coformer Screening of Multicomponent Crystals of Abiraterone Acetate Using Machine Learning (ML) and Multicomponent Hydrogen Bond Propensity (MCHBP): A Comprehensive Structural and Computational Investigation

Abstract Multicomponent crystalline systems offer a viable approach to improving the physicochemical and pharmacokinetic properties of drugs, thereby enabling the rational optimization of solid forms through coformer identification. The conventional process relies on empirical kn...

Dopamine alters macrophage metabolism promoting intracellular Mycobacterium tuberculosis survival

Dopamine (DA) is thought to aggravate progress of bacterial infections and enhance risk of intracellular bacterial infection like tuberculosis (TB). Though TB patients are known to present with high dopamine levels the causal link between them has remained unexplored. Mycobacteri...

Targeting Metallo-β-Lactamases:Discovery ofNovel Dihydro-Chromeno Pyrrole (dCPs) Derivatives for Combating Drug-ResistantInfections

Abstract Clinically approved therapies have established that combining β-lactam antibiotics with β-lactamase inhibitors is an effective strategy to counter antibiotic resistance; however, infections caused by metallo-β-lactamase (MBL) producing bacteria remain a critical unmet me...