National Institute of Pharmaceutical Education and Research

Nitrogen Doping Reduces the Neurotoxic Effects of Graphene Quantum Dots by Suppressing Proinflammatory and Oxidative Stress Pathways

Abstract Graphene quantum dots (GQDs) and their nitrogen-doped counterparts (N-GQDs) have recently been explored in the management of neurological disorders. However, their biocompatibility remains questionable, particularly subsequent to direct brain exposure. In this study, we...

Designed NIR-IEmissive and Selective G-QuadruplexDNA Binder with Altered Organelle Specificity

Abstract In this work, we report the discovery of a G-quadruplex DNA-selective and near-infrared (NIR-I) emissive G-quadruplex binder derived from a known styryl-quinolinium-based compound. This molecule is unique in its class, with an emission wavelength above 800 nm, and displa...

Micro and nanoplastic pollution in agricultural soils: effects on rhizosphere processes and phytotoxicity

Microplastic and nanoplastic (MPs/NPs) pollution is a major environmental threat affecting ecosystems and human health. Soils contain higher levels of MPs/NPs than oceans, underscoring the urgent need for improved plastic waste management in agriculture. Studies show that MPs/NPs...