National Institute of Pharmaceutical Education and Research

A Modification-Free Microneedle-Integrated Printed Electrochemical Sensor for Uric Acid Detection in Artificial Skin

Abstract The integration of microneedles (MNs) with electrochemical biosensors is a promising strategy for minimally invasive detection of metabolites from interstitial fluid (ISF). Conventional MN-based sensing platforms typically rely on conductive coatings or surface functiona...

Safety and efficacy of indigenous ultrathin-strut versus international thin-strut drug-eluting coronary stents in percutaneous coronary intervention: a systematic review of randomized controlled trials

Introduction Ultrathin-strut drug-eluting stents (DES) have been developed to enhance vascular healing and reduce restenosis following percutaneous coronary intervention (PCI). Indigenous biodegradable-polymer ultrathin-strut DES are increasingly used in high-burden settings; how...

Current Insights on CNS-Targeted Matrix Metalloproteinase Inhibitors for the Management of Alzheimer’s Disease

Matrix metalloproteinases, or MMPs, are enzymes that depend on zinc and play a key role in remodelling the extracellular matrix as well as regulating neuroinflammation within the central nervous system. There's growing evidence that when MMP activity is imbalanced, it contributes...

Nitrogen Doping Reduces the Neurotoxic Effects of Graphene Quantum Dots by Suppressing Proinflammatory and Oxidative Stress Pathways

Abstract Graphene quantum dots (GQDs) and their nitrogen-doped counterparts (N-GQDs) have recently been explored in the management of neurological disorders. However, their biocompatibility remains questionable, particularly subsequent to direct brain exposure. In this study, we...

Designed NIR-IEmissive and Selective G-QuadruplexDNA Binder with Altered Organelle Specificity

Abstract In this work, we report the discovery of a G-quadruplex DNA-selective and near-infrared (NIR-I) emissive G-quadruplex binder derived from a known styryl-quinolinium-based compound. This molecule is unique in its class, with an emission wavelength above 800 nm, and displa...

Micro and nanoplastic pollution in agricultural soils: effects on rhizosphere processes and phytotoxicity

Microplastic and nanoplastic (MPs/NPs) pollution is a major environmental threat affecting ecosystems and human health. Soils contain higher levels of MPs/NPs than oceans, underscoring the urgent need for improved plastic waste management in agriculture. Studies show that MPs/NPs...