National Institute of Pharmaceutical Education and Research

A Modification-Free Microneedle-Integrated Printed Electrochemical Sensor for Uric Acid Detection in Artificial Skin

Abstract The integration of microneedles (MNs) with electrochemical biosensors is a promising strategy for minimally invasive detection of metabolites from interstitial fluid (ISF). Conventional MN-based sensing platforms typically rely on conductive coatings or surface functiona...

Safety and efficacy of indigenous ultrathin-strut versus international thin-strut drug-eluting coronary stents in percutaneous coronary intervention: a systematic review of randomized controlled trials

Introduction Ultrathin-strut drug-eluting stents (DES) have been developed to enhance vascular healing and reduce restenosis following percutaneous coronary intervention (PCI). Indigenous biodegradable-polymer ultrathin-strut DES are increasingly used in high-burden settings; how...

Mechanistic insights into galantamine adsorption on SBA‐16 mesoporous silica: Kinetic and isotherm analysis

SBA-16 mesoporous silica particles (MSPs) with a cage-like architecture were synthesized and optimized for adsorption and controlled release of the BCS Class I drug galantamine hydrobromide. Optimized synthesis conditions produced monodisperse particle size (403 ± 26 nm, PDI 0.42...

Diosmetin attenuates chronic unpredictable mild stress induced-depression-like behavior in mice via modulation of oxidative stress, neuroinflammation, and the gut–brain axis

Depression is a highly prevalent affective disorder, and current pharmacotherapies are often limited by suboptimal efficacy and adverse effects. Diosmetin, a dietary flavonoid, exhibits neuroprotective properties through antioxidant and anti-inflammatory mechanisms; however, its...