National Institute of Pharmaceutical Education and Research

A Modification-Free Microneedle-Integrated Printed Electrochemical Sensor for Uric Acid Detection in Artificial Skin

Abstract The integration of microneedles (MNs) with electrochemical biosensors is a promising strategy for minimally invasive detection of metabolites from interstitial fluid (ISF). Conventional MN-based sensing platforms typically rely on conductive coatings or surface functiona...

Engineering metal‐organic framework‐based smart porous nanoplatforms for targeted therapy and theranostic applications

Abstract Metal‐organic frameworks (MOFs) are materials that have recently emerged with the potential for various biomedical applications. Through engineering MOFs to contain various components and functionalities, they have progressed from porous materials to “smart” MOFs that ca...

Safety and efficacy of indigenous ultrathin-strut versus international thin-strut drug-eluting coronary stents in percutaneous coronary intervention: a systematic review of randomized controlled trials

Introduction Ultrathin-strut drug-eluting stents (DES) have been developed to enhance vascular healing and reduce restenosis following percutaneous coronary intervention (PCI). Indigenous biodegradable-polymer ultrathin-strut DES are increasingly used in high-burden settings; how...

Integrated In Silico and Experimental Insights into Immunomodulatory Toll-Like Receptor 7/8 Agonists with Anticancer Potential

Abstract Toll-like receptors (TLRs) are key pattern recognition receptors that play a central role in regulating and bridging both innate and adaptive immune responses. Notably, TLR7 and TLR8 agonists have gained significant attention as promising therapeutic candidates because o...

Rational Coformer Screening of Multicomponent Crystals of Abiraterone Acetate Using Machine Learning (ML) and Multicomponent Hydrogen Bond Propensity (MCHBP): A Comprehensive Structural and Computational Investigation

Abstract Multicomponent crystalline systems offer a viable approach to improving the physicochemical and pharmacokinetic properties of drugs, thereby enabling the rational optimization of solid forms through coformer identification. The conventional process relies on empirical kn...

Inflammation biomarkers in cancer: mechanistic drivers, diagnostic innovations, and future clinical horizons

Chronic inflammation is a universally acknowledged characteristic of cancer, playing the role of a vital catalyst in cancer initiation and progression, and a chief predictor of the success or failure of cancer therapies. About 20% of all cancer cases are associated with states of...

White analytical chemistry-driven, blue-guided LC-MS/MS method for simultaneous quantification of metformin and sitagliptin in human plasma

Abstract A liquid chromatography-tandem mass spectrometry method was developed for the simultaneous determination of metformin (MET) and sitagliptin (SIT) in human plasma. Chromatographic separation was achieved on an Endurus C18 pro-XR 4.6 × 100 mm column, using methanol and 2 m...