National Institute of Pharmaceutical Education and Research

Unveiling the antidiabetic activity and potential molecular mechanisms of a polyherbal HP-β-cyclodextrin inclusion complex to reveal the integrated network pharmacology, docking studies against the PP242–mTOR complex and In-Vivo investigations

Type 2 diabetes mellitus (T2DM) is a rapidly increasing global health concern characterized by hyperglycemia, insulin resistance, and increased oxidative stress. Despite the availability of several antidiabetic therapies, long-term management remains challenging due to adverse ef...

Targeting Metallo-β-Lactamases:Discovery ofNovel Dihydro-Chromeno Pyrrole (dCPs) Derivatives for Combating Drug-ResistantInfections

Abstract Clinically approved therapies have established that combining β-lactam antibiotics with β-lactamase inhibitors is an effective strategy to counter antibiotic resistance; however, infections caused by metallo-β-lactamase (MBL) producing bacteria remain a critical unmet me...