National Institute of Pharmaceutical Education and Research

Dual targeting of cytochrome bd and bc1-aa3 terminal oxidases eradicates phenotypically diverse population of Mycobacterium tuberculosis

Bedaquiline approval paved the way for the development of drug candidates against energy metabolism pathways of TB-causing organisms, and oxidative phosphorylation was proven to be a relevant target domain. While bedaquiline acts on the F 1 F 0 ATP synthase, Q203 targets the cyto...

A Modification-Free Microneedle-Integrated Printed Electrochemical Sensor for Uric Acid Detection in Artificial Skin

Abstract The integration of microneedles (MNs) with electrochemical biosensors is a promising strategy for minimally invasive detection of metabolites from interstitial fluid (ISF). Conventional MN-based sensing platforms typically rely on conductive coatings or surface functiona...

Safety and efficacy of indigenous ultrathin-strut versus international thin-strut drug-eluting coronary stents in percutaneous coronary intervention: a systematic review of randomized controlled trials

Introduction Ultrathin-strut drug-eluting stents (DES) have been developed to enhance vascular healing and reduce restenosis following percutaneous coronary intervention (PCI). Indigenous biodegradable-polymer ultrathin-strut DES are increasingly used in high-burden settings; how...

Two‐Step, Telescopic Synthesis of Unsymmetrical Urea via Integration of Denitrogenative Methyl N ‐Arylcarbamates Formation and Their Aminolysis

Unsymmetrical ureas are valuable structural motifs in pharmaceuticals, agrochemicals, and functional materials; however, their synthesis often relies on toxic reagents, transition metals, or isocyanate intermediates, resulting in poor sustainability and limited scalability. Herei...

LC–HRMS/MS Characterization of Hydrolytic and Photolytic Degradation Pathways of Ripretinib Following Forced Stress Studies

ABSTRACT Introduction Ripretinib is an innovative multitargeted kinase inhibitor introduced for the treatment of advanced gastrointestinal stromal tumors, was investigated to elucidate its degradation behavior and structural transformation pathways under forced stress conditions....

Integrated In Silico and Experimental Insights into Immunomodulatory Toll-Like Receptor 7/8 Agonists with Anticancer Potential

Abstract Toll-like receptors (TLRs) are key pattern recognition receptors that play a central role in regulating and bridging both innate and adaptive immune responses. Notably, TLR7 and TLR8 agonists have gained significant attention as promising therapeutic candidates because o...

Unveiling the antidiabetic activity and potential molecular mechanisms of a polyherbal HP-β-cyclodextrin inclusion complex to reveal the integrated network pharmacology, docking studies against the PP242–mTOR complex and In-Vivo investigations

Type 2 diabetes mellitus (T2DM) is a rapidly increasing global health concern characterized by hyperglycemia, insulin resistance, and increased oxidative stress. Despite the availability of several antidiabetic therapies, long-term management remains challenging due to adverse ef...

Targeting Metallo-β-Lactamases:Discovery ofNovel Dihydro-Chromeno Pyrrole (dCPs) Derivatives for Combating Drug-ResistantInfections

Abstract Clinically approved therapies have established that combining β-lactam antibiotics with β-lactamase inhibitors is an effective strategy to counter antibiotic resistance; however, infections caused by metallo-β-lactamase (MBL) producing bacteria remain a critical unmet me...