National Institute of Mental Health and Neurosciences

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

Fragment-Based Discovery of BRD4-BD2 Selective Binders: Biophysical Validation and Structural Insights for Domain-Selective Inhibitor Design

Abstract BRD4, a member of the bromodomain and extra-terminal (BET) family of epigenetic readers, plays a central role in transcriptional regulation and is implicated in a wide spectrum of diseases. Although BRD4 inhibitors targeting both bromodomains have advanced into clinical...

The development and initial validation of the Perinatal Intrusions Interpretation Index: A novel scale that measures negative appraisals of infant‐related intrusive thoughts

OBJECTIVES: Unwanted and often distressing intrusive thoughts of infant-related harm are common during the perinatal period and are associated with poorer maternal mental health. The mechanisms linking perinatal intrusive thoughts to mental health remain poorly understood. One pr...

Effect of Add-on Integrated Yoga and Ayurveda Management on Clinical and Neurobiological Parameters in Multiple Sclerosis: A Randomized Controlled Trial Protocol

Background Multiple sclerosis (MS) is a progressive autoimmune neurodegenerative disorder characterized by inflammation, demyelination, and axonal damage. Current disease-modifying therapies demonstrate limited efficacy with substantial adverse effects. Ayurveda and yoga have dem...

Opioid-Sparing Versus Opioid-Based Analgesia for Craniotomy: A Multicenter Randomized Controlled Trial

Introduction: Pain control remains a challenge after neurosurgery. Opioid-sparing analgesia may provide better pain relief without opioid-related side effects after craniotomy. We aimed to compare analgesia requirement and postoperative pain between opioid-sparing and opioid-base...

Symptomatic Sclerosing Pneumocytoma of Lung: A Diagnostic Challenge with Diverse Morphological Patterns.

Background & Objective: Sclerosing pneumocytoma (SP), formerly termed sclerosing hemangioma, is a rare benign lung neoplasm often detected incidentally. Its histological diversity and dual cell population frequently complicate diagnosis, particularly in small biopsies. Case Prese...

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

WHO CNS5 mandates integrated histo-molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low- and lower-middle-income countries (LICs/LMICs), limiting implementation of molecularly in...