National Institute of Health Sciences

Management of metastatic spinal disease in low- and middle-income countries: an international survey of practices and challenges in Latin America

Spinal metastases impose urgent diagnostic and therapeutic demands; however, evidence from low- and middle-income countries (LMICs) in Latin America is sparse. We aimed to characterize real-world practices, access gaps, and priorities to in-form context-adapted guidelines. We con...

Strengthening the Genetic Evidence for the FLNA c.5776C>T (p.Pro1926Ser) Variant: Comments on Segregation, X-inactivation, and Digenic Considerations

Background: We read with interest the reported mother–daughter case series describing the novel heterozygous FLNA c.5776C>T (p.Pro1926Ser) variant associated with epilepsy and variable multisystem manifestations. Discussion: We highlight several considerations that may further st...

Transforming healthcare education: integrating the WHO rehabilitation competencies framework into interprofessional curricula

Abstract Background: The 2020 World Health Organization Rehabilitation Competencies Framework (RCF) provides a comprehensive foundation for developing interprofessional competencies across rehabilitation disciplines. However, limited awareness and systematic integration of this f...

Neonatal diethylstilbestrol exposure disrupts uterine epithelial apical–basal polarity and partial EMT state

Abstract The developing female reproductive tract is highly sensitive to external hormonal stimulation, which can result in infertility and gynecologic diseases. To determine the underlying mechanisms, we used a mouse model to test the immediate, cell type-specific effects of neo...

A Programmable Nanovesicle Platform for MegapascalPressure Sensing

Abstract Hydrostatic pressure (HP) is a subtle yet pervasive force that shapes chemistry and biology from the ocean floor to living cells─yet real-time HP sensing at the microscale remains elusive. Here, we report pyrene-modified polyionic complex vesicles (Pyr-PICsomes) as a cla...