National Institute of Geriatrics, Rheumatology and Rehabilitation

Trends in Hospitalizations of Patients with Idiopathic Inflammatory Myopathies: Long-Term Observational Study, 2010–2024

Background/Objectives: Idiopathic inflammatory myopathies (IIMs) are very rare, chronic, immune-mediated diseases that clinically manifest with myositis symptoms and extramuscular manifestations. The rarity of the disease makes it difficult to conduct double-blind studies, and la...

Vagus nerve stimulation in rheumatic diseases: linking autonomic nervous system regulation, inflammation, and clinical outcomes

Patients with autoimmune and inflammatory diseases most often exhibit sympathetic overactivity and dominance at the expense of the parasympathetic system, including the vagus nerve. It leads to dysfunction of the negative feedback mechanism within the hypothalamic–pituitary–adren...

Decades of Research in the Chronic Disease Self-Management Program: A Systematic Review and Meta-Analysis of Long-Term Health Outcomes Across Countries.

. 2026;116(9): 1397-1408. https://doi.org/10.2105/AJPH.2025.308381).

Suspected shrinking lung syndrome: a rare pulmonary manifestation of systemic lupus erythematosus—a case-based review of an underrecognized condition

Shrinking lung syndrome (SLS) is a rare pulmonary manifestation of systemic lupus erythematosus (SLE). It is characterized by unexplained dyspnea, restrictive ventilatory defect, and diaphragmatic elevation without interstitial lung disease (ILD). A 32-year-old man with SLE prese...

Rosavin, but not its combination with salidroside, lowers total β-catenin in human osteoblast cultures: an exploratory in vitro study under mineralizing conditions

Abstract Osteoblast dysfunction and altered Wnt/β-catenin-dependent responses accompany bone-remodeling imbalance in rheumatic and degenerative joint disease. Rosavin and salidroside are constituents of Rhodiola rosea preparations used without prescription, and are always encount...

Impact of Biologic and Targeted Synthetic Therapies on Retinal and Choroidal Parameters Assessed by Optical Coherence Tomography Angiography

Background: To compare retinal microvascular parameters assessed by optical coherence tomography angiography (OCTA) among patients with axial spondyloarthritis (axSpA) receiving different biologic and targeted synthetic therapies and to evaluate the association between smoking st...