National Institute of Diabetes and Digestive and Kidney Diseases

Proliferative control of the saccular-stage developing mouse lung requires the histone methylation activity of KMT2D

KMT2D, the histone methyltransferase and core component of the COMPASS/MLL4 complex, has been implicated in developmental diseases such as Kabuki Syndrome, interstitial lung disease, and congenital diaphragmatic hernia, with clear links to pediatric pulmonary disorders. Despite t...