National Institute of Biomedical Research

Impact of praziquantel treatment and early reinfection patterns in a mixed Schistosoma mansoni and Schistosoma haematobium infection focus in the Democratic Republic of Congo

Objective To evaluate the impact of single versus mixed Schistosoma infections on the efficacy of PZQ treatment as well as on the dynamics of reinfection after treatment. Methods We followed 388 randomly selected residents of a village co‑endemic for Schistosoma haematobium and S...

Endogenous anti-Ebola virus GP 1,2 antibodies interfere with detection of secreted glycoprotein in the blood of EVD patients

ABSTRACT Ebola disease (EBOD) is a highly infectious disease with severe hemorrhagic symptoms. It is caused by orthoebolaviruses , which include the Ebola virus ( Orthoebolavirus zairense ) (EBOV) causing Ebola virus disease (EVD), the most lethal EBOD to humans. Through co-trans...

Early insights into predicted efficacy of Ebola monoclonal antibodies for the 2026 Bundibugyo virus disease outbreak

The 2026 Bundibugyo virus disease (BVD) outbreak in the DRC and Uganda raises urgent questions about the efficacy of existing Ebola virus (EBOV) monoclonal antibodies (mAbs) against Bundibugyo virus (BDBV). Here, we perform genomic and structural analyses of 44 BDBV sequences, in...

Measurement of binding antibodies to SARS-CoV-2 variants elicited by natural infection and COVID-19 vaccines in a sub-Saharan African population

Abstract Data on immune responses to COVID-19 vaccination in West and Central Africa remain limited, particularly with respect to antibody (Ab) binding across SARS-CoV-2 variants and for different types of vaccine platforms. We assessed anti-spike (anti-S) antibody binding to nin...

Influence of spatial connectivity on the spread of Mpox in Maï-Ndombe province, Democratic Republic of the Congo, 2025

<title>Abstract</title> <bold>Background</bold> The spread of Mpox in the DRC is strongly influenced by human mobility in a context of environmental constraints and inequalities in accessibility. The province of Maï-Ndombe, with its fragmented transport network and dependence on...

SARS-COv-2, influenza and other respiratory virus co-circulation during an outbreak in a rural health zone in Democratic Republic of Congo, 2024–2025

Little is known about the global impact of co-circulation and co-infection of COVID-19 and influenza in Democratic Republic of the Congo (DRC). This study aims at analyzing data on SARS-CoV-2, influenza and other respiratory viruses collected during an outbreak response in the ru...