National Institute of Biomedical Innovation, Health and Nutrition

Regional effect of population-based programs promoting salt reduction and potassium intake in Hokkaido: a post hoc analysis of the PoSPIP

Abstract The Population-based Sodium/Potassium Improvement Program is a nonrandomized population-based intervention implemented by the Japanese Society of Hypertension across multiple municipalities and workplaces in Japan. This post hoc regional analysis focused on two municipal...

Long-term immunoprophylaxis by TLR9 ligand mediates macrophage-ILC cross-talk against respiratory viral infection

Rapid development of host immunity is critical during the emergence of viral outbreaks when vaccines are not yet available. Here, we demonstrate that CpG oligodeoxynucleotide-schizophyllan complex (K3-SPG) induces antigen-independent, long-term protection against lethal respirato...

Carbohydrate-to-fat ratio is positively associated with comprehensive frailty across protein-intake levels in older adults

Abstract Purpose Diet influences frailty, and protein intake has been a prime focus of prevention. However, frailty remains prevalent, even among older adults with relatively high protein intake, suggesting the influence of remaining energy distribution between carbohydrates and...

Impact of Inhibitor Size and Flexibility on the Binding Pathways to c-Src Kinase

Abstract The conformational plasticity of protein kinases poses a challenge for inhibitor design, motivating the use of molecular dynamics (MD) simulations to study their dynamic binding processes. While conformational changes are increasingly discussed, the impact of drug compou...

The impact of achieving the national vegetable intake target on cardiovascular disease and healthcare expenditures in Japanese adults: a simulation study, 2021–2031

A diet low in vegetables is a notable risk factor for cardiovascular disease (CVD). In Japan, the average daily vegetable intake remains below the Health Japan 21 (Third term) target of 350 g. In this study, we used a simulation model to predict the impact of achieving this natio...

Naturally Occurring ZCCHC3 Variants Modulate Antiretroviral Activity in Cynomolgus Macaques

ABSTRACT Many mammalian cells restrict viral replication by utilizing various host restriction factors. We recently demonstrated that CCHC‐type zinc‐finger‐containing protein 3 (ZCCHC3) suppresses human immunodeficiency virus type 1 (HIV‐1) replication through multiple mechanisms...

Total energy expenditure assessed by doubly labeled water in patients with myotonic dystrophy type 1: Associations with body composition and functional status

Background & Aims Myotonic dystrophy type 1 (DM1) is frequently associated with metabolic abnormalities and altered body composition, yet energy metabolism under free-living conditions remains incompletely characterized. This study aimed to characterize total energy expenditu...

The association of corporate measures and health management initiatives with employee engagement in Japanese companies

Using data from 2,502 companies in Japan’s Health and Productivity Management Survey, this study examined determinants of employee engagement and corporate success. Regression analysis showed that hourly paid leave (adjusted odds ratio [aOR]: 1.29, 95% CI: 1.07–1.56) and communic...

Standardization of shotgun metagenomics parameters for pks-positive enterobacteria detection in human fecal samples: Receiver operating characteristic analysis using polymerase chain reaction as reference standard

Enterobacteria harboring the polyketide synthase ( pks ) island ( clbA – clbS ), which encodes colibactin ( pks⁺ enterobacteria), is a putative risk factor for colorectal cancer. Polymerase chain reaction (PCR) is the current standard for detection. Primer-independent shotgun met...