National Institute of Biomedical Genomics

Dapagliflozin impairs renal epithelial innate immunity and facilitates uropathogenic E. coli infection in diabetes

Risk of pyelonephritis is very high among patients with diabetes. During diabetes, the oral antidiabetic drug, dapagliflozin (DAPA) is commonly prescribed for its well-recognized renoprotective effects. Although DAPA lowers renal glucose reabsorption, it significantly increases u...

Transcriptomic trajectory of hepatocyte ballooning reveals a lipotoxic point of no return and initiates oncogenic regulatory rewiring in MASLD

Background Hepatocyte ballooning is a defining histological marker of progressive steatohepatitis, but its molecular basis remains poorly defined. Objective To identify a molecular signature and mechanistic trajectory underlying hepatocyte ballooning across the MASLD-to-hepatocel...