Institution
National Institute of Biological Sciences, Beijing
Recent research
- BiologyOpen access
Meiotic recombination in reproductive cells is initiated by DNA double-strand breaks (DSBs) and requires the expression of meiosis-specific genes, yet how the transcription of those genes is regulated in either meiotic or somatic cells remains unclear. Here, using a representativ...
- Health & Medicine
Abstract Late-stage oxidative remodeling of tropolone cores underpins the remarkable scaffold diversity in fungal meroterpenoid biosynthesis. However, the mechanistic basis by which a single enzymatic catalyst diverts a common substrate toward carbon-excising ring contraction ver...
- BiologyOpen access
The circadian clock orchestrates a variety of physiological and behavioral processes, endowing the ability to adapt to the cycling environment. Here, we report the identification of TTRP, a TDP-43 pseudogene that emerged in higher Hominoidea species ~8.6 Mya. TTRP is a human test...
- BiologyOpen access
PIK3CA promotes hepatic tumor growth through evasion of phagocyte-mediated anti-tumor immunity
Both primary and metastatic liver cancers are highly lethal diseases, for which effective treatment options remain limited. The unique hepatic microenvironment provides a niche that enables tumor cells to evade immune surveillance. To identify factors that mediate tumor growth wi...
- BiologyOpen access
Small extracellular vesicles (sEVs) are functional carriers of biomolecules from host cells, making them highly suitable for early disease diagnosis and monitoring disease progression. However, the purification of sEVs from plasma is complicated by the presence of high levels of...