National Institute for Medical Research

Childcare in Transition: Evidence That Patterns of Childcare Differ by Degree of Market Integration in Northwestern Tanzania

Highlights This study uses novel data on multiple childcare types from both kin and nonkin in two culturally similar communities with varying market integration. It tests the hypothesis that market integration is associated with reduced kin support. Who provides support and the t...

Genomic epidemiology reveals geographically structured co-circulation of AFR10 and AFR13 Vibrio cholerae lineages driving cholera outbreaks in Tanzania (2022–2024)

Cholera remains a persistent public health challenge in Tanzania, with recurrent outbreaks across multiple regions overwhelming the health systems. Despite the ongoing surveillance to control the transmission, limited genomic characterization of circulating Vibrio cholerae strain...

Insecticide resistance profile and efficacy of next-generation LLINs against pyrethroid-resistant Anopheles gambiae s.l. in M’bé, central Côte d’Ivoire

Long-lasting insecticidal nets (LLIN) combining pyrethroids with synergists or partner insecticides represent the next-generation tools for controlling malaria transmitted by resistant vectors. Because of their differing modes of action, their deployment in a given area would req...

Diagnostic performance of a centrifugation-free stool processing kit in conjunction with Xpert®MTB/RIF Ultra for paediatric tuberculosis: a multicentre prospective study in five low and middle-income countries

Diagnosing paediatric tuberculosis (TB) remains challenging. Currently available diagnostic tests have limited accuracy, and most sampling methods are invasive. In 2021, the World Health Organisation (WHO) endorsed the use of molecular WHO-recommended rapid diagnostic tests (mWRD...

Metagenomic Profiling of Diarrheagenic Escherichia coli Pathotypes Reveals Predominance of Diffusely Adherent and Enteroaggregative Subtypes and Mixed Signatures Among Under-Fives in Tanzania

Diarrheagenic Escherichia coli (DEC) is a leading enteric pathogen in children under five in sub-Saharan Africa, yet conventional targeted assays fail to capture mixed virulence signatures or provide quantitative context relative to E. coli carriage. We applied a virulence-aware...