National Institute for Communicable Disease Control and Prevention

QHHP Ameliorates MASH Through Modulation of a Cyp4a32–PPARγ–CD36‐Associated Lipotoxic Axis

Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive stage of metabolic dysfunction-associated fatty liver disease, for which effective pharmacological therapies remain limited. Qinggan Huatan Huoxue Prescription (QHHP) has been used clinically in the manageme...

The enhanced importance of CD4+ T cell based monitoring of microbial flora in patients with HIV

Individuals infected with human immunodeficiency virus (HIV) frequently display diminished CD4 + T Cell levels, heightening susceptibility to diverse infections and imposing substantial burdens alongside life-threatening risks. This study aimed to compare lung microbial communiti...

Complex exposure–response relationships between meteorological factors and severe fever with thrombocytopenia syndrome risk

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease influenced by meteorological factors. This study aimed to characterize the complex exposure–response relationships between multiple meteorological factors and SFTS risk in Anhui Provin...

Library strategies differentially shape microbial, functional, and host signals in clinical metagenomic sequencing

Metagenomic next-generation sequencing (mNGS) is increasingly used in infectious disease diagnostics, yet how library preparation shapes the microbial, functional, and host signals recovered from clinical samples remains poorly defined. Here, we performed a within-sample parallel...

Rickettsia japonica strain YC21 from a fatal human case in China: comparative genomics and experimental characterization of infection phenotypes

Rickettsia japonica causes Japanese spotted fever (JSF), an emerging severe tick-borne disease in East Asia. We recently isolated strain YC21 from the first laboratory-confirmed fatal JSF case in China. This study aimed to characterize the genomic features and infection phenotype...

Biofilm formation and genomic signatures of circulating Bordetella pertussis strains isolated in Beijing, China

Abstract Background Pertussis, an acute respiratory infection caused by Bordetella pertussis ( B. pertussis ), has resurged in China. Biofilm formation has recently been associated with the pathogenesis of B. pertussis . This study aims to analyze the biofilm formation capacity o...

Detection and Distribution of Tick-Borne Bacterial Pathogens in Ticks from Different Hosts in the Altun Mountains, China

Background: Ticks are the main vectors for a variety of tick-borne bacterial pathogens. Systematic studies on the coinfection patterns and differences of pathogens in ticks derived from different hosts are of great significance. Therefore, the present study investigated ticks col...

Global Trends in Antimicrobial Resistance-Related Mortality from Klebsiella pneumoniae-Associated Lower Respiratory Infections: A GBD 2021 Analysis, 1990–2021

Klebsiella pneumoniae (K. pneumoniae) is a leading cause of hospital- and community-acquired lower respiratory infections (LRI). The emergence of antimicrobial resistance (AMR), especially carbapenem-resistant strains (CRKP), poses a serious global health threat. Using Global Bur...

An orthogonal transcription system enables high-efficiency rescue of measles virus-based vaccine vectors against multiple pathogens

Recombinant measles virus (rMeV) vectors are promising platforms for vaccine development against emerging infectious diseases due to their safety, stability, and potent immunogenicity. However, conventional rMeV rescue systems frequently exhibit low efficiency, thereby constraini...