National Hospital Organization Kyushu Cancer Center

Potential utility of more subtle microsatellite instability for predicting response to nivolumab in gastric cancer patients

The relationship between microsatellite instability (MSI) - high (H) and deficient DNA mismatch repair is, in fact, not straightforward. MSI observed in genome-edited cells carrying Lynch syndrome mutations is not so drastic as in typical MSI-H ( i.e. Type B mode) but uniformly m...

Summary of Research: HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination with Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer

This is a summary of a research article reporting the findings of the HER2CLIMB-05 trial (NCT05132582), a randomized, double-blind, placebo-controlled, international, phase III trial. The HER2CLIMB-05 trial was conducted to compare the efficacy and safety of adding tucatinib vers...

New and emerging somatostatin therapies for neuroendocrine tumors: “what is in the pipeline”

INTRODUCTION: Somatostatin receptors (SSTRs) have played a central role in all aspects of the management of neuroendocrine/endocrine neoplasms (NENs). This includes in diagnosis of NENs with the widespread use of radiolabeled SSTR ligands to localize both the primary tumor locati...

Institutional enrollment volume and clinical outcomes after surgery or chemoradiotherapy for clinical stage I esophageal squamous cell carcinoma: a supplementary analysis of JCOG0502

Abstract Background Surgery and chemoradiotherapy (CRT) are standard options for clinical stage I esophageal squamous cell carcinoma (ESCC). JCOG0502, a multicenter, non-randomized, parallel-group comparison, demonstrated the non-inferiority of definitive CRT compared with surger...

P1.236. Surgical Decision Model for Elderly Patients With Esophageal Cancer: Development and Validation of a Geriatric Stage (gStage) System

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The increasing age of patients with esophageal cancer poses significant challenges in surgical decision-making. Elderly individuals frequently present with multimorbidity, im...