National Hospital Organization

MRI findings and pathological features of angiofibroma of soft tissue mimicking soft tissue sarcoma: five case reports and a literature review

Angiofibroma of soft tissue (AFST) is a rare, benign fibroblastic tumor that is difficult to distinguish from malignancies based on radiological and pathological findings. While several reports have described the clinicopathological findings of AFST, there remains little informat...

Prion-like transmission of human tau strains in the mouse brain

Abstract Most neurodegenerative diseases are thought to spread through the brain by prion-like mechanisms, in which filamentous protein assemblies self-propagate by templated seeding 1 . Distinct conformations of amyloid filaments may provide the physical basis for the strains th...

B-cell infiltration in inclusion body myositis: association with inflammasome-related signaling and enhanced myotoxicity

Inclusion body myositis (IBM) is a degenerative, intractable, inflammatory myopathy with an immune pathomechanism. CD8+ T cell-mediated myocytotoxicity is considered a pivotal inflammatory pathogenic mechanism in IBM; however, there have been limited pathological investigations i...

Synergistic Effect of Ambient Ozone, Relative Humidity, and Temperature on Epidemic Patterns of Influenza: A Hypothesis and Its Verification

The mechanisms underlying seasonal patterns in influenza epidemics have long been an enigma. Our laboratory study revealed that ambient ozone significantly inactivates airborne influenza viruses synergistically with higher relative humidity and temperature. This led us to hypothe...

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and...

Evaluation of the UK Myeloma Research Alliance risk profile in transplant‐ineligible multiple myeloma patients treated with novel agents

Summary The heterogeneity of multiple myeloma (MM) significantly impacts treatment outcomes. Myeloma risk profile (MRP), introduced by the UK Myeloma Research Alliance, is a novel prognostic model for patients with transplant‐ineligible newly diagnosed MM (TIE‐NDMM) utilizing eas...

Genomic and clinicopathologic analysis of conventional dendritic cell sarcomas coexisting with myeloid neoplasms

Abstract Langerhans cell sarcoma (LCS), malignant indeterminate dendritic cell tumor (IDCT), and interdigitating dendritic cell sarcoma (IDCS) are rare malignant neoplasms that originate from antigen-presenting conventional dendritic cells (cDCs). These tumors, collectively terme...

Nintedanib Treatment of Patients With Interstitial Lung Diseases: A Retrospective Study of Daily Clinical Practice

Background/Aim: Nintedanib, an antifibrotic drug, is expected to slow the progression of interstitial lung diseases (ILDs). This study aimed to evaluate the usefulness of nintedanib for patients with idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF) who...

Remarkable Response to Immune Checkpoint Inhibition After Early Aggressive Recurrence Following Robot‐Assisted Radical Cystectomy for Bladder Squamous Cell Carcinoma: A Case Report

ABSTRACT Introduction Squamous cell carcinoma is a rare bladder cancer subtype with poor prognosis in advanced stages. Currently, there is no established systemic therapy, including immune checkpoint inhibitors, for this subtype. Case Presentation A 49‐year‐old man with pure blad...

Exploring Patient Needs and Respective Contributing Factors Regarding Hospital and Community Pharmacists for Outpatients with Cancer

Improving the quality and safety of outpatient chemotherapy requires effective information sharing between hospitals and community pharmacies. However, achieving truly patient-centered care necessitates pharmacists to go beyond information exchange and develop a deeper understand...

An autopsy study of a patient with refractory status epilepticus: MRI findings and histopathological correlation

Abstract Background Status epilepticus (SE) has been defined as a seizure that persists for more than 5 min. If SE persists despite benzodiazepine and appropriately dosed antiseizure medications, it could be regarded as refractory SE (RSE). New-onset refractory status epilepticus...