National Heart, Lung, and Blood Institute

Clathrin recruitment and assembly of phosphorylated B cell receptor is impaired in human diffuse large B cell lymphoma

The B cell receptor (BCR) drives the differentiation of naive B cells into activated plasma cells that produce antibodies. The BCR consists of a plasma membrane-bound surface immunoglobulin (sIg) that binds antigens, and two coreceptor subunits CD79A and CD79B. The intracellular...

Multi-Field Relaxation Dynamics of Parahydrogen-Hyperpolarized Propane Gas MRI Contrast Agent

Abstract Hyperpolarized gas-phase MRI is an emerging diagnostic modality, with the clinical utility of hyperpolarized Xe-129 gas for functional lung imaging recently supported by FDA regulatory approval. However, the requirement for dedicated multi-nuclear hardware and complex, c...

Epigenome-Wide Association Study of Abdominal Aortic Aneurysm Identifies Central Role for Inflammatory Pathways

BACKGROUND: Epigenetic mechanisms underlying susceptibility to abdominal aortic aneurysm (AAA) remain poorly understood. Identifying causal DNA methylation markers for AAA can elucidate the regulatory processes that drive aneurysm formation and accelerate translational applicatio...

Factors associated with longitudinal survey adherence and smartwatch usage among older adults in the electronic Framingham Heart Study

Sustaining long-term adherence to digital health protocols remains a major challenge, and factors influencing sustained use of digital devices among older adults are poorly understood. We identified sociodemographic, health-related, and technological factors associated with longi...

A Fast and Parallelized Procedure for Checking Molecular Dynamics 3D Structure

ABSTRACT Structures built for or generated from Molecular Dynamics simulations can often have problems such as wrong chiralities, bad parameter assignment, steric clashes, and/or distorted geometries. It is important to be able to detect such problems in a rapid and automated way...

The role of chloride ions in serotonin transport

Abstract The human serotonin (5-HT + ) transporter SERT facilitates 5-HT + transport into cells by coupling it to Na + symport and K + antiport. Although extracellular Cl − is also essential for transport, Cl − co-transport has been disputed, raising questions about the role of C...

Rethinking Complement in Homeostasis and Disease

The complement system, traditionally viewed as a central component of immune defense, is now recognized to play diverse roles in morphogenesis, tissue regeneration, cellular metabolism, and intercellular communication. This expanded perspective highlights the spatially distribute...

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

Bone marrow failure syndromes across the age spectrum: diagnostic and therapeutic principles

Bone marrow failure syndromes (BMFS) are a diverse group of disorders that commonly present with pancytopenia and require a structured approach to evaluation. Initial assessment focuses on excluding reversible causes, followed by consideration of inherited and acquired conditions...