National Health and Family Planning Commission

Epidemic Trends and Associated Factors of the Double Burden of Malnutrition Among Children and Adolescents in Xizang: Based on Five Cross-Sectional Surveys from 2019 to 2024

Introduction: The population-level double burden of malnutrition (DBM), characterized by the coexistence of undernutrition and overnutrition, presents a complex public health challenge. Xizang (Tibet), with its extreme high-altitude geography, rapid economic growth, and targeted...

PAK4 exacerbates melanoma immunosuppression by promoting exosome release

Melanoma remains a lethal malignancy with frequent resistance to immune checkpoint blockade therapy. Clinical evidence associates elevated PAK4 expression with poor response to anti-PD-1 treatment in melanoma patients. While tumor-derived exosomes are recognized as key immunosupp...

PediatricLiver score: a novel risk score for screening elevated liver stiffness in the pediatric population (CHESS2401)

Given the looming crisis of rapid increase in childhood obesity globally, chronic metabolic diseases have consequently emerged but without sufficient awareness among children. Reliable and accessible screening tools thus are required to screen for significant liver fibrosis in th...

Rotational stability and visual outcomes of toric implantable collamer lenses in eyes with horizontal and non-horizontal implanting orientation: an observational study

PURPOSE: To evaluate the short-term rotational stability and visual outcomes of the toric intraocular collamer lens (TICL) with horizontal and non-horizontal implantation orientation based on the Callisto eye system. METHODS: This observational study analyzed 77 eyes from 51 pati...

Plasma interleukin-1 receptor antagonist in pediatric patients as a potential biomarker for sepsis-associated acute kidney injury: a cohort study

Our goal is to evaluate the potential of interleukin-1 receptor antagonist (IL-1Ra) as a biomarker for sepsis-associated acute kidney injury (SA-AKI). Specifically, we aim to explore the correlation between acutely elevated endogenous IL-1Ra and SA-AKI, and to identify the potent...

Zoonotic and prey-derived protozoa in Tibetan fox ( Vulpes ferrilata ) and other wild canids: Implications for public health in the eastern Tibetan Plateau

Enteric protozoan infections-cryptosporidiosis, giardiasis, microsporidiosis, and coccidiosis-constitute a significant global burden on human and animal health. Yet comprehensive parasitological surveys of wildlife in the eastern Tibetan Plateau, where anthropogenic, livestock, a...

Bardoxolone methyl exerts an inhibitory effect on respiratory syncytial virus infection by downregulating IL-6 via the IKKβ/NF-κB signaling pathway

ABSTRACT Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections in infants, older adults, and immunocompromised individuals, but therapeutic options for active infection remain limited. Interleukin-6 (IL-6) contributes to RSV replication and RSV-induce...

Novel Compound-Heterozygous Variants in PYCR1 Expand the Variant Spectrum of Autosomal Recessive Cutis Laxa

Background and Objectives: Autosomal recessive cutis laxa (ARCL) is a genetically heterogeneous group of connective-tissue disorders characterized by loose, inelastic skin and variable systemic involvement. Biallelic variants in PYCR1 are associated with PYCR1-related ARCL, inclu...

Coffee, the Gut Microbiome, and Host Metabolism: Gastrointestinal Fate, Microbial Transformation, Mechanistic Insights, and Prospects for Precision Nutrition

Coffee is one of the most widely consumed beverages worldwide and a major dietary source of bioactive compounds, including caffeine, chlorogenic acids (CGAs), trigonelline, non-digestible polysaccharides, and roasting-derived melanoidins. Habitual coffee consumption has been asso...

Prevalence and risk factors of comorbidities among Chinese older people living with HIV/AIDS: a cross-sectional study

With population aging among people living with HIV/AIDS (PLWHA), comorbidity has become a prominent challenge for long-term care. However, evidence on its prevalence and associated factors in Chinese community settings remains limited. We conducted a cross-sectional study among P...

Emerging perspectives and promising solutions: lactylation modification in chemo- and radiotherapy of cancer

Protein lactylation modification represents an emerging post-translational protein modification that regulates protein function through the covalent attachment of lactate to protein lysine residues, thereby linking epigenetic regulatory mechanisms to cellular metabolic activities...

Joint associations of non-intact family types and health-risk behaviors with mental health outcomes: evidence from a large-scale survey among adolescents in Shandong Province, China

Rising global divorce rates have increased the prevalence of non-intact families, which may be associated with adolescents’ behaviors and mental health. Non-intact family types (NIFTs) and health-risk behaviors (HRBs) are both associated with adolescent mental health, yet previou...

Climate change reshapes the potential transmission risk of human alveolar and cystic echinococcosis in western China: a projection based on MaxEnt models

BACKGROUND: Echinococcosis, a severe zoonotic parasitic disease, imposes a significant health burden in western China, primarily as alveolar (AE) and cystic (CE) forms caused by Echinococcus multilocularis (Em) and E. granulosus sensu lato (Egsl), respectively. Its transmission,...

The Health Education Specialist Practice Analysis III 2025 (HESPA III 2025): Process and Outcomes

The Health Education Specialist Practice Analysis III 2025 was conducted to update and validate the hierarchical model associated with the contemporary framework for the practice of health education specialists across work settings at entry and advanced levels. The purpose of thi...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Computational Oncology of Chemotaxis-Driven Tumour–Immune Spatial Patterning and Stability

We develop a reaction–diffusion–chemotaxis model for spatial tumour–immune–chemokine dynamics that couples logistic tumour growth, immune-mediated killing, chemokine-dependent immune recruitment, chemotactic migration, and signal production. For the non-dimensional system, we est...

Protocol for the ACTIVE trial: a multicentre, open-label, cluster-randomized controlled trial of a quality improvement programme for older adults with hip fracture in resource-limited hospitals in China

Aims The primary aim of the Action on Hip Fracture Management Quality Improvement (ACTIVE) trial is to evaluate whether a context-tailored quality improvement programme improves health-related quality of life at 120 days after hospital admission, among adults aged 65 years or old...

Efficacy and evidence certainty of traditional Chinese exercises for musculoskeletal disorders: an umbrella review of meta-analyses

Objectives To comprehensively evaluate the efficacy and exercise prescription parameters of traditional Chinese exercises (TCEs) on health outcomes in patients with musculoskeletal disorders (MSDs) and rigorously assess the certainty of the evidence. Design Umbrella review. Data...

Association of prenatal exposure to PM2.5 and its chemical constituents with early childhood obesity: A population-based study

A growing body of evidence links gestational fine particulate matter (PM 2.5 ) exposure to elevated childhood obesity risk, yet research on the combined impacts and respective contributions of different PM 2.5 chemical constituents remains limited. This large population-based pro...

2-Ethylhexyl diphenyl phosphate exposure is associated with poorer overall survival in advanced high-grade serous ovarian cancer: Integrated epidemiological and experimental evidence implicating the ITGB1–FAK–AKT axis

Background Organophosphate esters (OPEs) are globally used flame retardants and plasticizers with widespread human exposure. Whether OPE exposure affects survival in advanced high-grade serous ovarian cancer (HGSOC) and the underlying mechanisms remains unclear. We aimed to ident...