National Engineering Research Center of Human Stem Cells

High sperm DNA fragmentation is associated with increased embryonic chromosomal abnormality: a retrospective study of 8 years involving 5637 couples undergoing ART

Abstract STUDY QUESTION Does sperm DNA fragmentation impair blastocyst chromosomal integrity? SUMMARY ANSWER A high sperm DNA fragmentation index (DFI) is associated with an increased risk of blastocyst aneuploidy, particularly when the man has poor semen quality or when the fema...