National Defense Medical College

A case of renal hypouricemia type 1 associated with compound heterozygous URAT1/SLC22A12 variants A209V and F379L: clinical evidence for their pathogenic significance

Abstract Renal hypouricemia (RHUC) is an inherited renal tubular disorder characterized by low serum uric acid levels and excessive urinary uric acid excretion due to impaired urate reabsorption in proximal tubules. Type 1 RHUC (RHUC1) is caused by pathogenic variants in URAT1/SL...

Spectral imaging for differentiating intrapancreatic accessory spleen from hypervascular pancreatic neoplasms using single-phase post-contrast CT

Abstract Objectives To evaluate the diagnostic performance of spectral imaging for differentiating intrapancreatic accessory spleen (IPAS) from hypervascular pancreatic neoplasms using portal-venous phase (PVP) spectral CT. Materials and methods This retrospective study included...

Co-exposure and interaction effect of a mixture of metals and polycyclic aromatic hydrocarbons on sperm oxidative damage

The study examined interactions between 16 polycyclic aromatic hydrocarbons (PAHs) and six metals in relation to sperm oxidative damage. PAH exposure was assessed using personal breathing-zone measurements, while metal exposure was quantified using urinary concentrations. Semen o...

The First Evidence of Intermittent Rectal Prolapse in a Wild Chimpanzee ( Pan troglodytes )

BACKGROUND: Rectal prolapse in wild chimpanzees has been rarely reported. We document a case of rectal prolapse in a wild young male chimpanzee at Mahale Mountains National Park, Tanzania. METHODS: An affected young male in the Mahale M group was observed with photographs/video a...

Image Quality of 1.5 T MRI Using Dual‐Type Deep Learning Reconstruction for Pancreatic Cystic Lesions: An Exploratory Comparison With Conventional 3 T MRI Without Deep Learning Reconstruction

ABSTRACT Background Dual‐type deep learning reconstruction (DLR) may improve the pancreatic MRI image quality; however, the effects of different DLR strengths at 1.5 T compared with the conventional 1.5 T and 3 T MRI without DLR remain unclear. Purpose To evaluate the image quali...

Desmoplastic reaction at the invasive front of upper urinary tract urothelial carcinoma: prognostic impact and associations with tumour invasiveness and immune–inflammatory status

Desmoplastic reaction (DR), characterised by myxoid stroma and keloid-like collagen, is a poor prognostic factor in several types of cancer. We investigated the impact of stromal DR status on recurrence and prognosis in patients with upper urinary tract urothelial carcinoma (UTUC...

Context-dependent lysophosphatidic acid signalling in inflammation: evidence hierarchy, myeloid regulation and translational gaps

BACKGROUND: Lysophosphatidic acid (LPA) has been extensively reviewed in receptor pharmacology, fibrosis, cancer, vascular biology and neural injury. Its role in inflammation remains difficult to interpret because well-replicated pathogenic or pro-remodelling actions coexist with...