National Cheng Kung University Hospital

Necrotising enterocolitis triggers a TNF-driven gut-blood-brain cascade that disrupts the blood-brain barrier and induces TNFR1-skewed neuronal apoptosis and pyroptosis

Necrotising enterocolitis (NEC) in very-low-birthweight (VLBW) infants is associated with neurodevelopmental difficulties, but the mechanisms linking intestinal disease to brain injury remain unclear. We asked whether NEC propagates along a tumour necrosis factor alpha (TNF-α)-ce...

Transforming naval organizations in the digital age: leadership, AI and dynamic capabilities for change

Purpose Indonesia, with over 17,000 islands and one of the world's longest coastlines, faces escalating geopolitical dynamism, maritime tensions, and transnational threats such as narcotics trafficking, piracy and illegal fishing. As the principal naval defense force, the Indones...

Two Faces of the Right Ventricle in Fabry Cardiomyopathy: Septal-Coupled and Atrial-Coupled Strain Patterns and Their Differential Associations with Enzyme Replacement Therapy

Right ventricular global longitudinal strain (RVGLS) and right ventricular free-wall longitudinal strain (RVFWLS) are both used to assess right ventricular involvement, but they include different myocardial components. We examined their cross-sectional correlates and longitudinal...

Tumor-derived RPS19 engages C5AR1+ inflammatory macrophages to drive astrocyte reprogramming and glioblastoma progression

Glioblastoma (GBM) is an incurable brain tumor with poor survival outcomes. Its progression and recurrence are strongly influenced by infiltrative growth of tumor cells and tumor microenvironment (TME) components, particularly tumor-associated macrophages (TAMs). To identify pote...

Magneto-Electronically Coupled Quasiparticle Statesin Monolayered MoS2 Driven by the Proximity Effect of UltrathinSmFeO3

Abstract The magnetic proximity effect (MPE) of magnetic substrates provides an effective route to manipulate spin/valley-dependent quasiparticles in two-dimensional transition-metal dichalcogenides (TMDs) without requiring large external magnetic fields. Herein, we demonstrate a...

Prevention of new-onset chronic kidney disease with renin–angiotensin system blockers in type 2 diabetes with preserved kidney function

Renin–angiotensin system (RAS) blockers, including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), are known to slow chronic kidney disease (CKD) progression in patients with established renal impairment. However, whether RAS blockade ca...

Effects of Ageism, Depression, Physical Resilience, and Frailty on Quality of Life Among Older Women

In Taiwan, as a super-aging society, older women face unique challenges that affect their health and quality of life (QoL). The present 1-year longitudinal study was conducted to examine changes in physical and psychosocial health and the relationship between these factors and Qo...