National Centre for Infectious Diseases

Escalating pyrethroid resistance in Anopheles funestus increases Plasmodium transmission

<title>Abstract</title> <bold>Background:</bold> The swift rise in pyrethroid resistance among malaria vectors poses a significant challenge to global malaria control. Although vector control tools have advanced, limited understanding of the vectorial capacity of highly pyrethroi...

Risk of new‐incident mental health diagnoses following SARS ‐ CoV ‐2 infection amongst children and young adults in Singapore: a retrospective cohort study

Background Mental‐health‐disorders in children/young adults increased post‐pandemic; however, the absence of linkage to COVID‐19 registries made direct attribution of psychological sequelae to acute infection challenging. Methods Healthcare‐claims databases in Singapore were util...

Autonomous intranasal delivery systems for central nervous system therapeutics

Intranasal delivery provides a rapid, non-invasive route to the central nervous system, bypassing the blood-brain barrier and first-pass metabolism. However, its therapeutic potential remains constrained by the nasal cavity's complex anatomy, the restricted surface area and perme...