National Center of Neurology and Psychiatry

Lack of Effect of Chlordiazepoxide on the Number of Falls in a Novel Falling‐Trap Test in Male C57BL / 6N Mice

Behavioral tests in mice and other animals are widely used to study anxiety and to evaluate the efficacy of anxiolytic compounds. However, the validity of behavioral tests used to assess anxiety-like behavior has been questioned because their results are often inconsistent and no...

Predictive processing as a scalable computational principle for embodied multitask intelligence

Humans exhibit remarkable flexibility in adapting to diverse and uncertain environments—a hallmark arising from the brain’s ability to integrate multimodal sensory streams into coherent predictive models. Drawing on this principle, we introduce a scalable hierarchical multimodal...

Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress

LRRK2, the Parkinson's disease-associated kinase, phosphorylates a subset of Rab GTPases and regulates membrane dynamics. We previously reported that lysosomal stress activates LRRK2 and thereby induces the exocytic secretion of lysosomal contents, but the detailed secretion mech...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...