National Center of Neurology and Psychiatry

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Post-traumatic stress disorder (PTSD) is a mental health disorder triggered by exposure to a traumatic event, which manifests with anguish, intrusive memories, and negative mood changes. So far, there is no efficient treatment for PTSD other than symptomatic palliative care. Howe...

Automated quantification of spinal axis distortion for behavioral assessment after spinal cord injury in mice

Spinal cord injury (SCI) causes persistent locomotor deficits that are commonly evaluated in mouse SCI models using observational scoring systems such as the Basso Mouse Scale, which primarily assesses hindlimb function. Here, we established an automated behavioral analysis pipel...

Parkinsonism with Reduced Striatal Uptake on DAT-SPECT in a Patient Harboring a Novel KCND3 Variant

KCND3 encodes the voltage-gated potassium channel Kv4.3, and pathogenic variants in KCND3 are associated with spinocerebellar ataxia type 19/22 (SCA19/22) and related neurological phenotypes. Here, we report a Japanese patient harboring a novel KCND3 missense variant, classified...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Spinal interneuronal populations encode static hindlimb posture in the cat

Proprioceptive signals from primary afferents often correlate with single-joint states (but can also reflect multi-joint configuration), whereas neuronal populations in the cerebral cortex represent limb endpoint postures. Where and how this transformation emerges along the somat...

Volume‐based stereotactic radiofrequency thermocoagulation for focal cortical dysplasia: A potentially safer alternative to resection in insulo‐opercular and central regions

Abstract Objective Deep white matter infarction caused by injury to the medullary arteries is a crucial cause of postoperative neurological deficits following surgical resection of focal cortical dysplasia (FCD) in the central and insulo‐opercular cortices. Volume‐based radiofreq...

Harm Reduction-Oriented Occupational Therapy for Substance Use Disorders: A Retrospective Cohort Study

ImportanceIdentifying factors associated with sustained engagement in harm reduction-oriented occupational therapy may help inform more accessible interventions for individuals with substance use disorders (SUDs).ObjectiveTo examine participant characteristics associated with sus...

Long-term effects of cognitive-behavioral therapy for adults with ADHD: results from an 8-year randomized controlled trial follow-up

Abstract Background To evaluate the provisional long-term durability of group cognitive behavioral therapy (CBT) benefits 8 years post-baseline and to explore tentative associations between digital booster engagement and the maintenance of treatment gains in adults with ADHD. Met...

Predictive processing as a scalable computational principle for embodied multitask intelligence

Humans exhibit remarkable flexibility in adapting to diverse and uncertain environments—a hallmark arising from the brain’s ability to integrate multimodal sensory streams into coherent predictive models. Drawing on this principle, we introduce a scalable hierarchical multimodal...

Lack of Effect of Chlordiazepoxide on the Number of Falls in a Novel Falling‐Trap Test in Male C57BL / 6N Mice

Behavioral tests in mice and other animals are widely used to study anxiety and to evaluate the efficacy of anxiolytic compounds. However, the validity of behavioral tests used to assess anxiety-like behavior has been questioned because their results are often inconsistent and no...

Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress

LRRK2, the Parkinson's disease-associated kinase, phosphorylates a subset of Rab GTPases and regulates membrane dynamics. We previously reported that lysosomal stress activates LRRK2 and thereby induces the exocytic secretion of lysosomal contents, but the detailed secretion mech...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...