National Center of Biomedical Analysis

Nicotinamide suppresses cytosolic DNA-Driven immunity independent of NAD+ via epigenetic modulation

Dysregulation of cytosolic DNA-triggered IFN-I signaling is a key driver of autoimmune and autoinflammatory pathogenesis. Precise metabolic orchestration of cytokine signaling is critical for immune homeostasis, but the role of endogenous metabolites in fine-tuning IFN-I transcri...