National Center for Immunization and Respiratory Diseases

Epidemiology and Trends of Corynebacterium diphtheriae in the United States, 2016—2023

Abstract Background Diphtheria, commonly resulting in severe respiratory or cutaneous disease, is caused by toxigenic strains of Corynebacterium diphtheriae; non-toxigenic strains can also cause disease. In the United States, only toxigenic disease is reportable, and the Centers...

Trends in Diarrhea-associated Mortality in Children Less Than 5 Years of Age in the United States, 2005–2024

BACKGROUND: The introduction of rotavirus vaccines in the United States in 2006 and 2008 has had large impacts on reducing rotavirus- and diarrhea-associated healthcare utilization. We evaluated changes in diarrhea-associated mortality from 2005 to 2024 among children 1-59 months...

Effectiveness of RSV Prevention Strategies in US Infants: 2024–2025

OBJECTIVE: In 2023, 2 products, a long-acting monoclonal antibody (nirsevimab) and maternal respiratory syncytial virus (RSV) vaccination, were recommended in the United States to prevent severe RSV disease among infants in their first RSV season. Low uptake during the 2023 to 20...