National Center for Global Health and Medicine

Geneformer-guided multiomics integration identifies Pbx1 as a network hub of hematopoietic stem cell aging

Hematopoietic stem cells (HSCs) constitute an organized hematopoietic system that undergoes age-related alterations, including increased platelet production and decreased erythropoiesis. The fundamental mechanisms driving these shifts remain incompletely understood. We used singl...

Working conditions, career barriers and perceived equity among neuro-oncology professionals: insights from the Japan society for neuro-oncology (JSNO) gender equality and diversity committee survey

<title>Abstract</title> Background Gender equity, work–life balance, and career development have become important concerns in the medical profession. However, empirical evidence on how neuro-oncology professionals experience working conditions, career barriers, and perceived ineq...

De-escalation of perioperative systemic therapy for early breast cancer.

Breast cancer is the most common malignancy among women worldwide, and the number of survivors continues to increase owing to earlier detection and advances in treatment. As long-term survivorship becomes increasingly important, minimizing treatment-related toxicity without compr...

A holistic approach to type 1 diabetes: From advances in science and technology to equity in diabetes care

Over the past century, the discovery of insulin transformed type 1 diabetes from a fatal disease into a manageable chronic condition, and the subsequent recognition of its autoimmune basis laid the foundation for screening and intervention before clinical onset. Building on these...

Association between awareness of government notification and ‘negative hepatitis virus test result card’ and implementation of hepatitis B and C screening in Japanese workplaces: a cross-sectional study

Abstract Background ‘Request for cooperation on measures against viral hepatitis in the workplace’ (the notification) was issued to provide hepatitis screening opportunities in workplaces. However, employees may take hepatitis tests multiple times because the results are not reco...

Balancing Circulatory Support and Ventricular Unloading in Post‐Infarction Ventricular Septal Perforation: A Computational Analysis of ECPELLA Support Configurations

BACKGROUND: Ventricular septal perforation (VSP) is a catastrophic complication of acute myocardial infarction frequently associated with cardiogenic shock. Combined venoarterial extracorporeal membrane oxygenation (VA-ECMO) and Impella support (ECPELLA) has emerged as a promisin...