National Center for Global Health and Medicine

Integrating the social and solidarity economy into global health: towards structural transformation for equity, resilience, and sustainability

Abstract Global health is shaped by complex and interdependent challenges across social, commercial, environmental, technological, and political domains that cannot be solved by the health sector alone. In response, alternative economic models and paradigms have gained attention....

Fatal Dilated Cardiomyopathy and Monogenic Diabetes Mellitus as SMPD4 ‐Related Disorder

ABSTRACT Sphingomyelin phosphodiesterase 4 (SMPD4)‐related disorder is a rare neurodevelopmental disorder caused by biallelic loss‐of‐function variants in SMPD4, characterized primarily by severe neurological manifestations. A subset of long‐term survivors develops diabetes melli...

Comparative genomics of Actinomyces identifies an MRONJ-associated lineage characterized by variation in mfd

Abstract Although many cases of medication-related osteonecrosis of the jaw (MRONJ) have been reported, its pathophysiology remains unclear. Additionally, previous histological and metagenomic studies have implicated an association between MRONJ and Actinomyces ; however, verific...

Single‐Cell RNA Sequencing‐Based Identification of Novel Podocyte Injury‐Associated Genes From Isolated Glomeruli of Diabetic db/db Mice

ABSTRACT Podocyte injury is a primary driver of progression in diabetic kidney disease (DKD). Although single‐cell RNA sequencing (scRNA‐seq) is a powerful tool for identifying novel disease‐associated genes, podocytes are frequently underrepresented in whole‐kidney scRNA‐seq dat...

Segmental arterial mediolysis developing during treatment for severe acute pancreatitis

Abstract We describe a case of segmental arterial mediolysis that developed during treatment for severe acute pancreatitis. The patient is a 41-year-old male who was hospitalized for severe alcoholic pancreatitis. The clinical course of acute pancreatitis was favorable. On the 10...

Successful hemodialysis withdrawal with glucocorticoid treatment after achieving infection control in a case of crescentic IgA-dominant staphylococcus-associated glomerulonephritis

Abstract Staphylococcus-associated glomerulonephritis (SAGN) is a subtype of infection-related glomerulonephritis (IRGN) that often affects older adults and can progress rapidly. The role of immunosuppressive therapy in IRGN remains controversial due to the risk of worsening infe...

Diabetes Trajectory and Pancreatic Cancer Detection in Patients with Diabetes: A Nationwide Survey Through Japan Diabetes Society-Certified Facilities

Background/Objectives: Diabetes mellitus (DM) and pancreatic cancer (PC) have a bidirectional relationship. Although new-onset DM (NODM) is recognized as a potential clue to PC, worsening glycemic control in long-standing DM (LSDM) may also precede PC diagnosis. We aimed to chara...

National Essential Diagnostics List development as an opportunity to expand frontline diagnostic testing at barangay health stations in the Philippines

The Philippines’ Universal Health Care Act places primary care at its center, yet the barangay health station (BHS), the facility closest to most community members, generally lacks diagnostic capacity. As the Philippines develops a National Essential Diagnostics List, this presen...

Real-World Longitudinal Treatment Outcomes for Patients with Metastatic Castration-Sensitive Prostate Cancer in Japan

With recent approvals in Japan, identifying optimal first-line therapy for metastatic castration-sensitive prostate cancer (mCSPC) is critical. We evaluated real-world outcomes of androgen-deprivation therapy (ADT) plus androgen receptor signaling inhibitors (ARSIs) as first-line...

A divergent betacoronavirus with a functional furin cleavage site in South American bats

Abstract Bats are natural reservoirs for a wide range of RNA viruses. Members of the genus Betacoronavirus , including Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) and Middle East Respiratory Syndrome virus (MERS-CoV), have attracted particular attention due to their re...

Cytokine upregulation and ocular surface dysbiosis in lacrimal drainage pathway disease and its associated keratopathy: a prospective multicenter observational study

Abstract Background To elucidate the pathogenesis of lacrimal drainage pathway disease-associated keratopathy (LDAK), we investigated the cytokine profile in tear fluid and the ocular surface microbiome in patients with lacrimal duct disorders. Methods This multi-center prospecti...

Implementing collaborative learning platforms for healthcare quality improvement in Lao PDR: a case study of national forums

Abstract Background Healthcare quality and safety initiatives in low- and middle-income countries often face fragmentation due to varying stakeholders’ readiness levels. Collective learning facilitates knowledge exchange and institutional capacity building, which are crucial for...

Protocol of the STRIDE-X study: a multicenter, single-arm trial of single tremelimumab regular interval durvalumab followed by hepatectomy for initially unresectable hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) ranks as the fifth most common cancer globally and the third leading cause of cancer-related death. Systemic therapies such as lenvatinib or the combination of atezolizumab and bevacizumab has recently emerged as a first-line the...

Characterisation of a human monoclonal antibody targeting a conserved epitope at the base of the HA head of influenza A(H3N2) virus

Background Numerous broadly reactive human monoclonal antibodies (mAbs) against the haemagglutinin (HA) of influenza A viruses have recognised conserved epitopes across HA subtypes or within subtypes. Most heterosubtypic mAbs target the HA stem, the receptor-binding site (RBS), o...

Geneformer-guided multiomics integration identifies Pbx1 as a network hub of hematopoietic stem cell aging

Hematopoietic stem cells (HSCs) constitute an organized hematopoietic system that undergoes age-related alterations, including increased platelet production and decreased erythropoiesis. The fundamental mechanisms driving these shifts remain incompletely understood. We used singl...

Working conditions, career barriers and perceived equity among neuro-oncology professionals: insights from the Japan society for neuro-oncology (JSNO) gender equality and diversity committee survey

<title>Abstract</title> Background Gender equity, work–life balance, and career development have become important concerns in the medical profession. However, empirical evidence on how neuro-oncology professionals experience working conditions, career barriers, and perceived ineq...

De-escalation of perioperative systemic therapy for early breast cancer.

Breast cancer is the most common malignancy among women worldwide, and the number of survivors continues to increase owing to earlier detection and advances in treatment. As long-term survivorship becomes increasingly important, minimizing treatment-related toxicity without compr...

A holistic approach to type 1 diabetes: From advances in science and technology to equity in diabetes care

Over the past century, the discovery of insulin transformed type 1 diabetes from a fatal disease into a manageable chronic condition, and the subsequent recognition of its autoimmune basis laid the foundation for screening and intervention before clinical onset. Building on these...

Association between awareness of government notification and ‘negative hepatitis virus test result card’ and implementation of hepatitis B and C screening in Japanese workplaces: a cross-sectional study

Abstract Background ‘Request for cooperation on measures against viral hepatitis in the workplace’ (the notification) was issued to provide hepatitis screening opportunities in workplaces. However, employees may take hepatitis tests multiple times because the results are not reco...

Balancing Circulatory Support and Ventricular Unloading in Post‐Infarction Ventricular Septal Perforation: A Computational Analysis of ECPELLA Support Configurations

BACKGROUND: Ventricular septal perforation (VSP) is a catastrophic complication of acute myocardial infarction frequently associated with cardiogenic shock. Combined venoarterial extracorporeal membrane oxygenation (VA-ECMO) and Impella support (ECPELLA) has emerged as a promisin...