National Center for Geriatrics and Gerontology

Differences in Occupational and Health Accommodations for Older Workers by Workplace Size: A Text Mining Analysis of Open-Ended Responses

Abstract Objectives As labor force participation among older workers continues to increase, the nature of workplace accommodations may vary according to workplace size. In this study, we aimed to clarify the current status and characteristics of workplace accommodations that addr...

Prostate cancer burden and attributable risk factors in East Asia from 1990 to 2021: a systematic analysis

Prostate cancer is a significant health concern in East Asia, where distinctive characteristics of disease presentation and outcomes warrant focused epidemiological investigation. This study evaluated the current status, future trends and risk factors across six East Asian region...

Validation and refinement of a biomarker panel for frailty assessment and prediction of muscle weakness in older adults

Abstract Frailty is a complex geriatric syndrome characterized by age-related declines in physiological function and cognitive reserve. To promote early prevention and intervention, minimally invasive and objective biomarkers that can detect frailty progression are required. We a...

Predictors of weight regain after weight loss in obesity: roles of birthweight, diet, and metabolic factors

Weight regain after weight loss is common in obesity. However, risk factors for weight regain remain uncertain, particularly with respect to developmental and dietary factors. This study aims to identify clinical, metabolic, developmental, and dietary predictors of weight regain....

Task-specific physiological signatures of perceptual and cognitive workload under cockpit noise: implications for pilot state monitoring and training

Cockpit noise is a common operational stressor that can affect pilots' mental workload and performance. This study examined whether multimodal physiological measures could show task-demand-dependent physiological signatures under cockpit-noise interference, and whether these resp...

Auditory Cueing in Spatial Neglect: Effects on Visual Search Depend on Auditory Spatial Performance.

Research on spatial neglect predominantly focuses on the visual domain, often conceptualising cross-modal spatial cueing as a potential means to ameliorate visuospatial performance. As spatial neglect can affect multiple sensory modalities, it is unclear how patients with differe...

Albumin-Based Biomarkers and Adverse Outcomes in Coronary Artery Disease: A Systematic Review and Meta-Analysis

Background: Albumin-based biomarkers have emerged as practical tools for prognostic assessment in coronary artery disease (CAD), but their comparative prognostic patterns and potential clinical utility have not been systematically evaluated. Methods: We performed a systematic rev...

Impaired liver-muscle lactate metabolism causes sarcopenia via lactic acidosis in skeletal muscle in mice

Sarcopenia is a progressive disease characterized by age-related decline in skeletal muscle force and mass. The fundamental molecular pathogenesis of sarcopenia has not yet been elucidated. Here, we show that the accumulation of lactate and intracellular acidification, lactic aci...