National Center for Genetic Engineering and Biotechnology

Rare WDR19 Variants in Patients With Dental and Retinal Anomalies

Genetic variants in WDR19 cause ciliopathies with craniofacial and ectodermal features, including dental and retinal anomalies. This study characterized the clinical and molecular features of patients with isolated dental anomalies harboring WDR19 variants. Clinical and radiograp...

Metabolic and Inflammatory Risk Stratification in Resected Cholangiocarcinoma: A Retrospective Exploratory Analysis

Background: Cholangiocarcinoma (CCA) frequently recurs after curative-intent resection. Metabolic alterations and systemic inflammation may contribute to aggressive disease, but their combined prognostic relevance remains unclear. Methods: We retrospectively reanalyzed 88 patient...

Gamma irradiation-induced metabolic reprogramming as a determinant of radiation tolerance in thai rice germplasm for space agriculture

Abstract Radiation beyond Earth’s atmosphere poses a major challenge for space agriculture by affecting seed viability and plant establishment. As a controllable terrestrial analogue of cosmic radiation, gamma (γ) irradiation provides a practical model for evaluating crop resilie...

Phenotypic and Genomic Analysis of Swine-Derived Bacillus subtilis 1BP1Co1 as a Functional Probiotic Candidate to Mitigate Escherichia coli-Associated Diarrhea

Post-weaning diarrhea caused by pathogenic Escherichia coli is a significant economic challenge in global swine production. Rising antimicrobial resistance linked to traditional antibiotics necessitates safe, sustainable alternatives. This study isolated and characterized host-as...