National Center for Epidemiology

The structure of the dopamine D 3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology

The third-generation antipsychotic cariprazine is a low-efficacy partial agonist of the dopamine D 3 receptor (D 3 R). Here, we report the cryo–electron microscopy structure of cariprazine bound to D 3 R, establishing a framework for understanding ligand recognition in this recep...

The Universal Boundary Quotient of an Observed Representation: Maximal Equivariant Structure and an Exact Tripartite Conservation Law

AbstractA representation resolves some perturbations of a system and leaves others undetected, and the orbit-stabiliser relation makes that division an exact two-term conservation law. Between the perturbations that move nothing and those that move the output without law lies a t...