National Center For Child Health and Development

Maternal COVID-19 During Pregnancy and Offspring Neurodevelopmental Disorders

Background: Maternal coronavirus disease 2019 (COVID-19) during pregnancy was common during the pandemic. However, its potential risks for clinically diagnosed neurodevelopmental disorders in offspring, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum di...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Cesarean delivery and overweight at 6 years of age: a prospective cohort analysis of the Japan Environment and Children’s Study

Abstract Cesarean delivery (CD) has been suggested as a potential risk factor for childhood overweight and obesity; however, evidence beyond early childhood remains inconsistent. We examined the association between CD and childhood overweight at age 6 years and explored early lif...

Adolescent pregnancy and adverse maternal and perinatal outcomes: a systematic review and meta-analysis

Adolescent pregnancy remains a major global public health concern, yet evidence on its association with a broad range of maternal and perinatal outcomes remains fragmented. We conducted a systematic review and meta-analysis of observational studies comparing adolescents (13–19 ye...

The elongation of Mest transcript into MestXL sustains, but does not initiate, the maternal allele bias of its convergent gene Copg2 during neurogenesis

Abstract Precise gene dosage control is critical for cellular identity and development, particularly for imprinted genes, where dosage imbalances are linked to neurodevelopmental disorders. The Mest/Copg2 imprinted locus exemplifies this fine-tuned regulation: while Mest is const...

The future of allergy and immunology care: A perspective on innovation, equity, and global collaboration from the WAO Junior Members Group

Allergic and immunological diseases are among the fastest-growing non-communicable conditions worldwide, affecting all age groups and regions.1 The increasing burden of asthma, allergic rhinitis, atopic dermatitis, food allergy, and other immune-mediated conditions is driven by c...

Implementing and upscaling pregnancy and postpartum physical activity: a workgroup report from the international society of behavioral nutrition and physical activity — from individual-level barriers to multilevel implementation and scale-up

Abstract Background Physical activity during pregnancy and the postpartum period is important for maternal health, yet participation remains suboptimal, and the implementation and scale-up of physical activity initiatives across diverse cultural and health-system contexts remain...

Shall we score? The SHALL-WE score for optimizing sclerotherapy in superficial lymphatic malformations

No standardized tool guides the decision of when to escalate beyond sclerotherapy in lymphatic malformations (LMs). We developed the SHALL-WE score (Severity, Histology, And Location—Lymphatic malformation: When to Escalate) to define the optimal sclerotherapy threshold in superf...

Biliary complications in pediatric living donor liver transplantation: An international multicenter analysis of risk and prognostic factors

Biliary reconstruction is often considered the Achilles’ heel of liver transplantation, yet risk factors and outcomes remain poorly defined, particularly in pediatric living donor liver transplantation (LDLT). This international multicenter study aims to identify predictors of bi...

Burden and Risk Factors for Severe Respiratory Syncytial Virus Infection Among Pediatric Hematopoietic Cell Transplant Recipients

BACKGROUND: Respiratory syncytial virus (RSV) causes substantial morbidity in pediatric hematopoietic cell transplant (HCT) recipients; however, risk factors for severe disease remain incompletely characterized. METHODS: We conducted a multicenter retrospective cohort study acros...

What a wonderful world: beyond relapsed pediatric acute myeloid leukemia

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Long‐Term Restoration of Anticoagulant Function After Liver Transplantation for Severe Congenital Protein C Deficiency: A Single‐Center Experience Involving Three Pediatric Patients

Severe congenital protein C (PC) deficiency is a rare inherited coagulation disorder that can be difficult to control with conventional medical treatment alone. We report a single-center case series of three pediatric patients with severe congenital PC deficiency who underwent li...

Preoperative FIB ‐4 Index as a Potential Factor Associated With Severe Postoperative Complications and Endogenous Organ Failure After Hepatectomy for Hepatocellular Carcinoma

ABSTRACT Background Liver fibrosis influences tolerance to surgical stress, dictating postoperative complication risks after hepatectomy for hepatocellular carcinoma (HCC). While conventional systems assess hepatic function, they may not fully capture structural fibrosis. This st...

Futility and Termination of Resuscitation Variation for Pediatric Out-of-Hospital Cardiac Arrest

OBJECTIVES To evaluate agency-level differences in determinations of futility (defined as withholding resuscitative efforts by emergency medical services [EMS]) and termination of resuscitation (TOR) during prehospital encounters for pediatric out-of-hospital cardiac arrest (OHCA...

DNA methylation changes following rapid maxillary expansion in children

Rapid maxillary expansion (RME) is a widely used orthodontic intervention for correcting transverse maxillary deficiencies. By mechanically separating the midpalatal suture, RME improves occlusal relationships and induces tissue repair processes similar to fracture healing. Infla...

Common Food Emulsifiers Impair Epithelial Barrier Integrity and Trigger Pro‐Inflammatory Responses and IgE Production

The global rise in allergic and autoimmune diseases since the 1960s has been associated with environmental disruptions of epithelial barriers, particularly in the gastrointestinal tract. Among the implicated factors are food emulsifiers, which have become increasingly prevalent i...