National Cancer Center Hospital East

P1.102. A Study of Lymph Node Metastasis in cNo.104 Cases of Thoracic Esophageal Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background The JCOG1109 trial established docetaxel, cisplatin, and 5-fluorouracil (DCF) therapy as the standard preoperative treatment for locally advanced thoracic esophageal cancer, achieving improved local cont...

P1.157. International Comparison of Clinicopathologic Characteristics and Outcomes After Minimally Invasive transCervical Esophagectomy (MICE): A Retrospective Cohort Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Minimally Invasive transCervical Esophagectomy (MICE) avoids a thoracic approach via transcervical mediastinal and abdominal dissection. Preserving pleural integrity may reduce pulmonary complica...

De-escalation of perioperative systemic therapy for early breast cancer.

Breast cancer is the most common malignancy among women worldwide, and the number of survivors continues to increase owing to earlier detection and advances in treatment. As long-term survivorship becomes increasingly important, minimizing treatment-related toxicity without compr...

The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review

BACKGROUND: Cholangiolocarcinoma (CLC) is a rare liver cancer with ≥ 80% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial. We conducted a nationwide m...

Relationship between initial dose, dose intensity, and survival in unresectable pancreatic cancer treated with nanoliposomal irinotecan, fluorouracil, and folinic acid

Abstract While nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard second-line regimen for unresectable pancreatic cancer (uPC) after gemcitabine-based therapy, the effects of initial dosing and relative dose intensity (RDI) in routine practice are unc...

Circulating effector memory CD8 + T-cells predict tumor shrinkage and reflect wasting conditions and immunity in tocilizumab plus gemcitabine/nab-paclitaxel for mPDAC

Circulating levels of effector memory CD8 + T cells are associated with a better prognosis in patients with metastatic pancreatic ductal adenocarcinoma. The purpose of this study was to assess the effects of effector memory CD8 + T cells on tumor size and wasting conditions. In t...

Pharmacist–Physician Task Sharing for Anti-MRSA TDM Orders in a Cancer Center: A Retrospective Before-and-After Study

In August 2025, we implemented physician-pharmacist task sharing for therapeutic drug monitoring (TDM) of anti-methicillin-resistant Staphylococcus aureus agents. Before implementation, physicians entered initial and follow-up TDM orders after pharmacist feedback, but afterward,...

Gut microbial and metabolic biomarkers for early-onset colorectal cancer

Early-onset colorectal cancer (EO-CRC) is a growing global health challenge with poorly understood etiology. While gut microbiota and metabolites are implicated in colorectal carcinogenesis, EO-CRC-associated signatures remain poorly characterized. This study presents the first l...

Real-world safety and effectiveness of olaparib maintenance after first-relapse platinum-sensitive ovarian cancer in Japan: a multicenter historical cohort (JGOG3026)

OBJECTIVE: The primary objective of the study was to evaluate the safety and effectiveness of olaparib maintenance therapy in Japanese patients with platinum-sensitive first-relapsed ovarian cancer. The secondary objective was to survey the treatment given after the olaparib main...