National Academy of Medicine

Three vs. five trocar approach in laparoscopic sleeve gastrectomy: a comparative retrospective study of 100 patients

To compare operative outcomes, postoperative complications, and weight-loss effectiveness between three-trocar and conventional five-trocar laparoscopic sleeve gastrectomy (LSG). A retrospective cohort study of 100 patients undergoing LSG between 2022 and 2023 was conducted. Fort...

Clinical characteristics associated with failure to achieve a prespecified guideline-directed medical therapy target at discharge in patients with HFrEF undergoing scheduled hospitalization: a secondary analysis of the HEROES study

Abstract Guideline-directed medical therapy (GDMT) is crucial for the pharmacological management of heart failure (HF) with reduced ejection fraction (HFrEF). The aim of the study was to identify clinical characteristics associated with failure to achieve the prespecified stringe...

NDM-Producing Klebsiella pneumoniae Bloodstream Infection Increases Mortality and Impairs Hematopoietic Recovery in Acute Leukemia

Background: Bloodstream infections (BSIs) remain among the most serious complications of intensive chemotherapy for acute leukemia. Infections caused by New Delhi metallo-β-lactamase (NDM)-producing Klebsiella pneumoniae are associated with limited therapeutic options and poor pr...

Efficacy and tolerability of venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukemia – real-world analysis of Polish adult leukemia study group

We collected clinical data on 363 patients with relapsed/refractory chronic lymphocytic leukemia (RR-CLL) treated with venetoclax-rituximab (VR) in a real-world setting. The median age was 69.5 years (range, 32.5–91.6 years), and the median number of prior lines of therapy was 2...

Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML

Acute myeloid leukaemia (AML) is a therapeutically challenging malignancy driven by the self-renewal, quiescence, and therapy resistance of leukaemic stem cells (LSCs). CDK8, a kinase component of the Mediator complex, regulates oncogenic transcription, and the selective CDK8/CDK...