Narodowy Instytut Leków

Expanding the genotypic and phenotypic spectrum of PGAP1 deficiency: clinical and functional insights from 15 patients

Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are essential for neuronal development, synaptic organization and signaling. Defects in GPI-anchor biosynthesis or remodeling cause rare neurodevelopmental disorders, including post-GPI attachment to proteins 1 (PGAP1) defi...

Neuroprotective and Neuromodulatory Potential of Valeriana officinalis, Passiflora incarnata, and Ginkgo biloba: Efficacy, Safety, and Regulatory Aspects

Valerian (Valeriana officinalis L.), passionflower (Passiflora incarnata L.), and ginkgo (Ginkgo biloba L.) are among the most widely used medicinal plants in European phytotherapy, with well-documented traditional use for anxiety, insomnia, cognitive decline, attention-deficit/h...

Rosavin, but not its combination with salidroside, lowers total β-catenin in human osteoblast cultures: an exploratory in vitro study under mineralizing conditions

Abstract Osteoblast dysfunction and altered Wnt/β-catenin-dependent responses accompany bone-remodeling imbalance in rheumatic and degenerative joint disease. Rosavin and salidroside are constituents of Rhodiola rosea preparations used without prescription, and are always encount...