Institution
Nanyang Medical College
Recent research
- BiologyOpen access
Role of PANoptosis in cancer: molecular mechanisms and therapeutic insights
Abnormal cell death plays a crucial role in cancer development. Inducing tumor cell death is an important strategy for cancer treatment. Against this backdrop, with the in-depth study of the regulatory mechanisms of cell death, the discovery of interactions existing among pyropto...
- AI & ComputingOpen access
Computational thinking has become a foundational competency for 21st-century learners, yet effective and scalable approaches to its cultivation remain insufficient. This study addresses three persistent gaps in the literature: the lack of systematically integrated AI-assisted ped...
- Health & MedicineOpen access
Accurate stratification of acute cholecystitis (AC) severity and prognosis remains challenging. Leucine-richα-2-glycoprotein-1 (LRG-1) is an inflammatory biomarker, but its role in assessing AC severity has not been studied. This study aimed to investigate the diagnostic and prog...
- Engineering & TechnologyOpen access
Screening and ARTP mutagenesis-based breeding of high-cellulase-producing strains
Abstract While lignocellulose is an abundant renewable resource, the discovery of microorganisms capable of degrading lignocellulose is important for its full utilization. In this study, 26 soil samples were collected from Jigongshan National Nature Reserve, Xinyang, China. The C...
- Health & MedicineOpen access
To investigate risk factors for positive proximal and distal resection margins after surgery for esophageal squamous cell carcinoma (ESCC). Total initially enrolled esophageal squamous cell carcinoma patients were 148,121 cases. After strict case screening and quality control, a...
- Health & Medicine
A Randomized Placebo-Controlled Trial of HTD1801 Monotherapy in Participants With Type 2 Diabetes
OBJECTIVE: The safety and efficacy of HTD1801 versus placebo were evaluated in participants with type 2 diabetes inadequately controlled with diet and exercise. RESEARCH DESIGN AND METHODS: Key entry criteria of this phase 3, randomized, placebo-controlled trial included type 2 d...
- Health & MedicineOpen access
Abstract Therapeutic targets for gastric cardia adenocarcinoma (GCA), particularly for HER2-negative patients, are lacking. Here, we conducted multi-omics profiling on 128 GCA patients using mass spectrometry, whole-exome sequencing, RNA-Seq, scRNA-Seq and spatial transcriptomics...