Nanyang Institute of Technology

AI-driven drug design for head and neck squamous cell carcinoma using GNN and structure-based simulations

Head and neck squamous cell carcinoma (HNSCC) remains a major global health burden with limited targeted therapeutic options. Here we present an integrated artificial intelligence (AI)-driven drug discovery framework combining graph neural networks (GAT, GCN, AttentiveFP and GIN)...

Multi-omics profiling reveals gene signatures and therapeutic targets in HER2-guided gastric cardia adenocarcinoma patients

Abstract Therapeutic targets for gastric cardia adenocarcinoma (GCA), particularly for HER2-negative patients, are lacking. Here, we conducted multi-omics profiling on 128 GCA patients using mass spectrometry, whole-exome sequencing, RNA-Seq, scRNA-Seq and spatial transcriptomics...

Occurrence of Black Spot Caused by Alternaria alternata on Celosia cristata L. in Henan Province, China and In Vitro Screening of Control Agents

Celosia cristata is an important ornamental and medicinal plant widely cultivated in China. In July 2025, a severe black spot disease was observed on C. cristata in the Zhang Zhongjing Medicinal Plant Garden, Nanyang, Henan Province, China, resulting in substantial defoliation an...

An ElectronicallyCoupled Interfacial Energy Descriptorfor Predicting Coulombic Efficiency in Aqueous Zinc Batteries

Abstract Solid–liquid interfaces dictate the performance and longevity of aqueous batteries. While rationally designed electrolyte additives offer a potent strategy to stabilize these interfaces, the complex interactions between additives and metal surfaces are difficult to isola...

Low-carbon and sustainability considerations of soil waste stabilisation

The aim of this study is to propose a sustainable framework for soil stabilisation by integrating strength, durability, and stabiliser type (i.e. cement and soil stabiliser). A new index, Icse (i.e. (UCS100/UCS28)/(CO2×D)) was developed to reflect the relationship between unconfi...

Contrasting Physiological Responses of Noni Seedlings to Acidic and Alkaline Soils and Their Differential Response to Biochar Amendment

Abstract The rapid expansion of Morinda citrifolia L. (noni) cultivation in tropical regions is driven by its recognized medicinal value, yet little is known about its agronomic and physiological responses to different soil environments. In particular, the effects of soil acidity...

Geosynthetic reinforcement and drainage in fine-grained embankments under rainfall

The increasing use of locally sourced fine-grained soils in embankment construction increases susceptibility to rainfall-induced instability due to low permeability, high water retention and limited shear strength. This study investigates the coupled reinforcement–drainage behavi...