Nanjing Traditional Chinese Medicine Hospital

Allostatic load, genetic susceptibility, and lung cancer risk: Evidence from a prospective cohort and integrative proteomic analyses

Allostatic load (AL), a composite measure of multisystem dysregulation associated with chronic stress, has been linked to lung cancer risk. However, its joint effects with genetic susceptibility and the biological pathways underlying this relationship remain unclear. We conducted...

Harnessing cell cycle synchronization to boost the therapeutic potential of umbilical cord MSCs against acute colitis

Abstract Human umbilical cord mesenchymal stromal cells (UCMSCs) are multipotent stem cells with strong immunomodulatory capacity, ease of acquisition, low immunogenicity, and a non-tumorigenic nature, making them attractive candidates for tissue repair. Under standard culture co...

miR‐7641: A Novel Diagnostic Biomarker for Rheumatoid Arthritis That Exerts Protective Effects by Targeting TNFSF10

ABSTRACT Rheumatoid arthritis (RA) is closely associated with genetic factors, but there is still a lack of ideal biomarkers for its early diagnosis and precise intervention. To investigate the diagnostic value and synovial cell function of miR‐7641 in RA, and its mechanistic lin...

Stimuli-responsive magnetic black phosphorus-based nanoreactor for chirality-dependent anoikis induction in cancer therapy

Anoikis presents an alternative scheme for suppressing tumor metastasis. While limited by off-target effects, rapid degradation, and reactive oxygen species (ROS) accumulation, anoikis resistance remains a persistent challenge for current tumor therapy. The use of external and en...

Intrinsic capacity, genetic susceptibility and incident inflammatory bowel disease: a prospective cohort study in UK Biobank

Abstract Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder, but whether intrinsic capacity (IC), a multidomain measure of functional reserve, is associated with incident IBD remains unclear. We analysed 427,489 UK Biobank participants free of IBD at baseline...

Quality and reliability of leukaemia-related short video content on Bilibili and TikTok: a cross-sectional study

Abstract Background Short‑video platforms have become a primary source of health information in China, yet the quality and reliability of disease‑related content remain largely unregulated. Numerous cross‑sectional studies have revealed suboptimal quality, significant platform di...

Remote electroacupuncture conditioning protects the heart via fine-tuning the dual role of the SDF-1α/CXCR4 axis in myocardial ischemia–reperfusion injury

BACKGROUND: Remote electroacupuncture (EA) conditioning on forearm protects against myocardial ischemia-reperfusion injury (MIRI). However, the cardioprotective mechanisms of RIC have not been fully elucidated. This study aimed to investigate whether EA could balance the pro-surv...

From multifaceted mechanisms to targeted strategies: advances in PANoptosomes as regulatory hubs of PANoptosis in cancer

Programmed cell death (PCD) is a fundamental barrier to tumorigenesis, but cancer cells often evolve ways to evade single-mode death pathways. PANoptosis is a newly recognized form of PCD that integrates features of pyroptosis, apoptosis, and necroptosis. PANoptosomes organize th...