Nanjing Municipal Center for Disease Control And Prevention

Analysis of Clinical Characteristics of Pertussis in Children Aged 0–6 Years in Tertiary and Pediatric Hospitals of Jiangsu Province from January to May 2024

Objective: To analyze the clinical manifestations and hospitalization-related factors among children with pertussis, and to provide scientific support for pertussis prevention, control, clinical diagnosis, and treatment. Methods: From January through May 2024, children aged 0–6 y...

Immunogenicity and Safety of a Single Booster Dose of Sabin-Strain Inactivated Poliovirus Vaccine in Adolescents and Adults: A Phase IV, Open-Label Trial

Background: In China, the current national immunisation schedule extends only to 4 years of age, and no polio booster dose is recommended for adolescents or adults, with data on immunogenicity and safety in these populations lacking. This phase IV trial evaluated the immunogenici...

Synergistic antitumor immune activation in melanoma using LA-PegPI polymeric gene vaccine in conjunction with PD-1 inhibition

Cancer gene vaccines are a promising avenue for cancer immunotherapy; however, their success depends not only on the gene construct itself but more critically on the efficacy and safety of the gene delivery vehicle. Targeting dendritic cells (DCs), the specialized antigen-present...