Nanjing Maternity and Child Health Care Hospital

The hDPSC-CM-derived peptide P1DC promotes osteogenic differentiation by regulating the p38/MAPK pathway

Human dental pulp stem cells (hDPSCs) are dental-derived mesenchymal stem cells with robust multipotent differentiation potential, indicating that they are promising for bone tissue engineering (BTE). We previously screened a secreted peptide, P1DC, derived from differentiated hD...

Assessment of the factors associated with initial treatment failure in cesarean scar pregnancy

This study identified factors associated with initial treatment failure in cesarean scar pregnancy (CSP) and provided insights to improve management strategies and patient outcomes. This retrospective study involved 451 electronic medical records of patients with CSP who were tre...

LPA deficiency in follicular fluid linked to impaired oocyte maturation through BCAA metabolism-mediated mitochondrial dysfunction

Abstract Lysophosphatidic acid (LPA) is known to be crucial for oocyte developmental competence, but the underlying molecular mechanisms remain unclear. In this study, we investigated the mechanistic relationship between follicular fluid LPA levels and oocyte quality determinants...

A three-metabolite microbiota-associated signature for early risk stratification of gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes and long-term metabolic and cardiovascular risk. However, oral glucose tolerance testing at 24–28 gestational weeks limits early risk stratification. Gut microbiota-associated metabolites may reflec...

Risk factors and a perioperative prediction model for postreperfusion syndrome in donation after circulatory death liver transplantation: a retrospective cohort study

Postreperfusion syndrome (PRS) is a common and clinically important complication during liver transplantation. It is characterized by marked hemodynamic instability after graft reperfusion and has been associated with adverse perioperative outcomes. However, perioperative factors...

Proteomic and metabolomic alterations in follicular fluid associated with embryological outcomes in women with isolated ANA-positive infertility: a prospective multi-omics cohort study

Autoimmune abnormalities are increasingly recognized as contributing factors to unexplained infertility. Among these, antinuclear antibodies (ANAs) are the most frequently detected autoantibodies and have been associated with adverse embryologic outcomes. However, the mechanisms...