Nanjing Maternity and Child Health Care Hospital

Serum Olink proteomics-based exploration of novel predictive biomarkers for necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal emergency in preterm infants, yet reliable serum candidates for presymptomatic risk stratification remain lacking. In this exploratory study, serial pre-diagnostic serum samples from a prospective discovery co...

Self-reported pain, depressive symptoms and risk for cardiovascular diseases

Previous studies have found that both pain and depressive symptoms are deleteriously associated with cardiovascular diseases (CVD). The aim of current study was to investigate the joint association of pain and depressive symptoms with CVD risk. A total of 13,184 participants aged...

Bidirectional Mediation Effects of Body Mass Index and Inflammatory Markers on Assisted Reproductive Outcomes in Women With Polycystic Ovary Syndrome

OBJECTIVE: To evaluate the bidirectional mediation effects of body mass index (BMI) and inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], systemic immune-inflammation index [SII], platelet-to-lymphocyte ratio [PLR]) on assisted reproductive technology (ART) outcomes in...

Onvansertib-mediated PLK1 inhibition impairs spermatogenesis in the murine testis

Onvansertib (ONV) is a selective inhibitor of polo-like kinase 1 (PLK1) and has promise in treating cancer. However, its potential effects on male reproductive function remain insufficiently characterized. In this study, male mice received clinically relevant doses of ONV by intr...

Early-pregnancy HOMA-IR and a maternal-side low-flow placental hypoechoic-space phenotype in pregnancies with maternal obesity: a prospective cohort study

Early maternal insulin resistance may be associated with placental vascular change in pregnancies with maternal obesity, but its relationship with an operationally defined maternal-side low-flow placental hypoechoic-space phenotype is unclear. This prospective cohort included 299...

Lipid-related metabolic indices and in vitro fertilization outcomes in women with polycystic ovary syndrome: a retrospective cohort study with mediation analysis

To examine the association between composite lipid-related metabolic indices and embryological outcomes in women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), and to test whether body mass index (BMI) and seru...

The hDPSC-CM-derived peptide P1DC promotes osteogenic differentiation by regulating the p38/MAPK pathway

Human dental pulp stem cells (hDPSCs) are dental-derived mesenchymal stem cells with robust multipotent differentiation potential, indicating that they are promising for bone tissue engineering (BTE). We previously screened a secreted peptide, P1DC, derived from differentiated hD...

Assessment of the factors associated with initial treatment failure in cesarean scar pregnancy

This study identified factors associated with initial treatment failure in cesarean scar pregnancy (CSP) and provided insights to improve management strategies and patient outcomes. This retrospective study involved 451 electronic medical records of patients with CSP who were tre...

LPA deficiency in follicular fluid linked to impaired oocyte maturation through BCAA metabolism-mediated mitochondrial dysfunction

Abstract Lysophosphatidic acid (LPA) is known to be crucial for oocyte developmental competence, but the underlying molecular mechanisms remain unclear. In this study, we investigated the mechanistic relationship between follicular fluid LPA levels and oocyte quality determinants...

A three-metabolite microbiota-associated signature for early risk stratification of gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes and long-term metabolic and cardiovascular risk. However, oral glucose tolerance testing at 24–28 gestational weeks limits early risk stratification. Gut microbiota-associated metabolites may reflec...

Risk factors and a perioperative prediction model for postreperfusion syndrome in donation after circulatory death liver transplantation: a retrospective cohort study

Postreperfusion syndrome (PRS) is a common and clinically important complication during liver transplantation. It is characterized by marked hemodynamic instability after graft reperfusion and has been associated with adverse perioperative outcomes. However, perioperative factors...

Proteomic and metabolomic alterations in follicular fluid associated with embryological outcomes in women with isolated ANA-positive infertility: a prospective multi-omics cohort study

Autoimmune abnormalities are increasingly recognized as contributing factors to unexplained infertility. Among these, antinuclear antibodies (ANAs) are the most frequently detected autoantibodies and have been associated with adverse embryologic outcomes. However, the mechanisms...