Nanjing Jiangning Hospital

Oral Nano-Oxygen Modulates the Intestinal HIF-2α/NEU3/Ceramide Axis to Mitigate NAFLD

Abstract The intestinal hypoxia-inducible factor-2α (HIF-2α)/neuraminidase 3 (NEU3)/ceramide axis has emerged as an important regulator of gut–liver communication in nonalcoholic fatty liver disease (NAFLD). However, systemic inhibition of HIF-2α may interfere with hepatic glucos...

Application effect of PBL combined with skeletal simulation-based surgical training teaching mode in orthopedic teaching

Orthopedics is a highly practical clinical discipline, and traditional single problem-based learning (PBL) teaching is limited by the lack of intuitive operational training, which easily leads to the disconnection between theoretical learning and clinical practice in medical stud...

Biliary microbiota associated with early postoperative stone reappearance under T-Tube surveillance: an exploratory 16 S rRNA sequencing study

Early postoperative stone reappearance after biliary surgery may reflect residual stones, early re-formation, or bile duct recolonization within an altered biliary environment. Although mechanical and anatomical factors are traditionally implicated in recurrent common bile duct s...