Nanjing General Hospital of Nanjing Military Command

Multimodal Transformer Integrating CT and Pathology for Postoperative Risk Stratification in Stage I Non–Small Cell Lung Cancer

A biologically interpretable multimodal artificial intelligence framework outperformed guideline-based postoperative risk stratification for stage I non–small cell lung cancer and identified patients who would benefit from adjuvant therapy.

A renal cyst-clear cell renal cell carcinoma comorbidity analysis identifies a FOXM1-positive epithelial COL6A1-CD44 axis that remodels fibroblasts

Background Renal cystic conditions are heterogeneous. We used a broad renal cyst-associated disease-gene framework to identify molecular programs shared with clear cell renal cell carcinoma (ccRCC), without modeling a specific cystic disorder or direct cyst-to-cancer progression....

Plasma multi-omics signatures of the EAT-Lancet diet and associations with health outcomes

The EAT-Lancet diet aims to optimize human health and environmental sustainability, but the biological changes associated with this dietary pattern remain incompletely characterized. We aimed to identify plasma proteomic and metabolomic signatures associated with adherence to the...

Association between age and outcomes of evidence-based feeding protocol versus usual care in critically ill patients: secondary analysis of a multicenter cluster-randomised controlled trial

BACKGROUND: Nutrition therapy is essential in critically ill patients, yet large randomised trials have shown inconsistent results regarding the effect of an evidence-based feeding protocol. The NEED trial showed a feeding protocol could effectively promote delivery of enteral nu...

Potential therapeutic effects of Lactobacillus on Pancreatic ductal adenocarcinoma through its metabolite Harmaline

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal form of cancer. Recent research has uncovered the role of the gut microbiota in influencing PDAC progression and treatment outcomes. Dysbiosis of gut microbiota in PDAC patients has been shown to negatively...

Noncanonical function of Claudin-1 mitigates lethal endoplasmic reticulum stress to drive prostate cancer lineage plasticity and chemoresistance

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (CRPC) driven by therapy-induced lineage plasticity. While endoplasmic reticulum (ER) homeostasis is critical for cell fate determination and therapeutic response, the molecular mech...

Early renal perfusion phenotypes and renal recovery in critically ill patients with or at risk for acute kidney injury: a prospective multicenter cohort study

BACKGROUND: Acute kidney injury (AKI) in critical illness is heterogeneous, and conventional Kidney Disease: Improving Global Outcomes (KDIGO) classification may not capture early physiologic differences relevant to renal recovery. METHODS: Critically ill adults with or at risk f...

Intratubular light chain amyloidosis: a comprehensive analysis of disease spectrum and clinicopathological characteristics

Abstract Background The disease spectrum of intratubular light chain amyloidosis (AL) remains unkown. Methods Patients with intratubular AL from a single center were retrospectively analyzed and stratified into 3 groups: Group 1, complicated by extra-tubular amyloidosis; Group 2,...

Association of transglutaminase-2 with contrast-induced acute kidney injury in Chinese patients with acute coronary syndrome: a prospective cohort study

BACKGROUND: To investigate the dynamic changes in serum and urinary Transglutaminase-2 (TG2) levels in acute coronary syndrome (ACS) patients and their association with contrast-induced acute kidney injury (CI-AKI), thereby providing novel clinical evidence for risk prediction of...